Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Roxithromycin
Drug ID BADD_D01975
Description Roxithromycin is a semi-synthethic macrolide antibiotic that is structurally and pharmacologically similar to [erythromycin], [azithromycin], or [clarithromycin]. It was shown to be more effective against certain Gram-negative bacteria, particularly _Legionella pneumophila_. Roxithromycin exerts its antibacterial action by binding to the bacterial ribosome and interfering with bacterial protein synthesis. It is marketed in Australia as a treatment for respiratory tract, urinary and soft tissue infections.
Indications and Usage Used to treat respiratory tract, urinary and soft tissue infections.
Marketing Status approved; investigational; withdrawn
ATC Code J01FA06
DrugBank ID DB00778
KEGG ID D01710
MeSH ID D015575
PubChem ID 444037
TTD Drug ID D0Y4FL
NDC Product Code Not Available
UNII 21KOF230FA
Synonyms Roxithromycin | Rulide | Infectoroxit | Rulid | Macrosil | MTW-Roxithromycin | Rotesan | Rotramin | Roxi 1A Pharma | Roxi-paed 1A Pharma | Roxi Basics | Roxi TAD | roxi von ct | Roxi-Puren | Roxi-Q | Roxi-saar | Roxi-Wolff | Roxibeta | roxidura | Roxigamma | Roxigrün | Roxihexal | Roxithro-Lich | RU 28965 | RU-28965 | RU28965 | RU 965 | RU-965 | RU965 | Biaxsig | Claramid
Chemical Information
Molecular Formula C41H76N2O15
CAS Registry Number 80214-83-1
SMILES CCC1C(C(C(C(=NOCOCCOC)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC( O3)C)N(C)C)O)(C)O)C)C)O)(C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain upper07.01.05.003--
Anaphylactic shock10.01.07.002; 24.06.02.004---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Asthma10.01.03.010; 22.03.01.002---
Bronchospasm10.01.03.012; 22.03.01.004--
Deafness04.02.01.001---
Dermatitis23.03.04.002---
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Diarrhoea07.02.01.001--
Discomfort08.01.08.003---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dyspepsia07.01.02.001--
Eosinophilia01.02.04.001--
Erythema multiforme10.01.03.015; 23.03.01.003--
Feeling abnormal08.01.09.014---
Flatulence07.01.04.002--
Fluid retention14.05.06.002; 20.01.02.003---
Generalised oedema08.01.07.004; 14.05.06.007--
Hallucination19.10.04.003--
Headache17.14.01.001--
Hepatitis cholestatic09.01.01.002---
Hepatocellular injury09.01.07.008---
Hypersensitivity10.01.03.003--
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030---
Laryngeal oedema10.01.05.003; 22.04.02.001; 23.04.01.005--
Malaise08.01.01.003--
Nail discolouration23.02.05.001--
Nausea07.01.07.001--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005; 23.03.03.094--
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