Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Riluzole
Drug ID BADD_D01942
Description A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi.
Indications and Usage For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)
Marketing Status approved; investigational
ATC Code N07XX02
DrugBank ID DB00740
KEGG ID D00775
MeSH ID D019782
PubChem ID 5070
TTD Drug ID D0H0KB
NDC Product Code 68462-381; 70510-2201; 42291-775; 0378-4145; 62756-538; 67877-286; 69076-200; 63278-1076; 65129-1011; 70515-700; 65977-0045; 66039-812
UNII 7LJ087RS6F
Synonyms Riluzole | 2-Amino-6-trifluoromethoxybenzothiazole | 2 Amino 6 trifluoromethoxybenzothiazole | Rilutek | RP-54274 | RP 54274 | RP54274 | PK-26124 | PK 26124 | PK26124
Chemical Information
Molecular Formula C8H5F3N2OS
CAS Registry Number 1744-22-5
SMILES C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eye disorder06.08.03.001---
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.004--
Facial paralysis17.04.03.008---
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014---
Flat affect19.04.01.004---
Flatulence07.01.04.002--
Fluid retention14.05.06.002; 20.01.02.003---
Fungal skin infection11.03.05.002; 23.11.03.006---
Furuncle11.02.05.008; 23.11.02.009---
Gait disturbance08.01.02.002; 15.03.05.013; 17.02.05.016--
Gamma-glutamyltransferase increased13.03.04.024--
Gastric ulcer07.04.03.002--
Gastritis07.08.02.001--
Gastrointestinal disorder07.11.01.001---
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009---
Gastrointestinal pain07.01.05.005--
Generalised oedema08.01.07.004; 14.05.06.007--
Gingival bleeding07.09.07.001; 24.07.02.010---
Glaucoma06.03.01.002--
Glossitis07.14.01.001---
Glycosuria20.02.01.005--
Gout14.09.01.001; 15.01.06.001---
Granuloma skin23.03.15.002---
Haematemesis07.12.02.002; 24.07.02.011---
Haematocrit decreased13.01.05.001---
Haematoma24.07.01.0010.000538%
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemoglobin13.01.05.018---
Haemoglobin decreased13.01.05.003---
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