Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Riluzole
Drug ID BADD_D01942
Description A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi.
Indications and Usage For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)
Marketing Status approved; investigational
ATC Code N07XX02
DrugBank ID DB00740
KEGG ID D00775
MeSH ID D019782
PubChem ID 5070
TTD Drug ID D0H0KB
NDC Product Code 68462-381; 70510-2201; 42291-775; 0378-4145; 62756-538; 67877-286; 69076-200; 63278-1076; 65129-1011; 70515-700; 65977-0045; 66039-812
UNII 7LJ087RS6F
Synonyms Riluzole | 2-Amino-6-trifluoromethoxybenzothiazole | 2 Amino 6 trifluoromethoxybenzothiazole | Rilutek | RP-54274 | RP 54274 | RP54274 | PK-26124 | PK 26124 | PK26124
Chemical Information
Molecular Formula C8H5F3N2OS
CAS Registry Number 1744-22-5
SMILES C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aspartate aminotransferase increased13.03.04.011--
Asphyxia12.01.08.011; 22.02.02.001---
Asthenia08.01.01.0010.002530%-
Asthma10.01.03.010; 22.03.01.002---
Ataxia08.01.02.004; 17.02.02.001--
Atrial fibrillation02.03.03.0020.001346%
Back pain15.03.04.005--
Biliary colic09.02.01.001---
Blepharitis06.04.04.001; 23.03.04.012---
Blood bilirubin increased13.03.04.018--
Blood creatine phosphokinase increased13.04.01.001--
Body temperature decreased13.15.01.010---
Body temperature increased13.15.01.001---
Bone disorder15.02.04.004---
Bone neoplasm15.09.02.001; 16.29.01.001---
Bradycardia02.03.02.002---
Breast abscess11.01.02.002; 18.06.02.002; 21.05.03.003---
Breast pain21.05.05.003--
Bronchiectasis22.03.02.0050.000538%-
Bronchitis11.01.09.001; 22.07.01.001--
Bundle branch block02.03.01.009---
Cardiac arrest02.03.04.0010.000808%
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002---
Cardiac murmur13.14.01.001---
Cataract06.06.01.001--
Cellulitis11.02.01.001; 23.11.02.004---
Cerebral artery embolism17.08.01.001; 24.01.04.001---
Cerebral haemorrhage17.08.01.003; 24.07.04.001---
Cerebral ischaemia17.08.01.005; 24.04.06.003--
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