Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Rifapentine
Drug ID BADD_D01937
Description Rifapentine is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.
Indications and Usage For the treatment of pulmonary tuberculosis.
Marketing Status approved; investigational
ATC Code J04AB05
DrugBank ID DB01201
KEGG ID D00879
MeSH ID C018421
PubChem ID 135403821
TTD Drug ID D0G9IU
NDC Product Code 40074-0009; 0088-2102; 50090-5063; 68022-7055; 53002-1718
UNII XJM390A33U
Synonyms rifapentine | 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin | 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin SV | DL 473-IT | Rifapex | Priftin | DL 473 | DL-4-73 | MDL 473
Chemical Information
Molecular Formula C47H64N4O12
CAS Registry Number 61379-65-5
SMILES CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C) OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C6CCCC6)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.001540%
Abortion18.01.01.001---
Abscess11.01.08.001---
Acne23.02.01.001---
Ageusia07.14.03.003; 17.02.07.001---
Aggression19.05.01.001---
Agitation17.02.05.012; 19.06.02.001--
Alanine aminotransferase increased13.03.04.005--
Alcohol abuse19.07.06.001---
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.003---
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.0010.002054%-
Asthma10.01.03.010; 22.03.01.002---
Azotaemia20.01.01.001---
Back pain15.03.04.005--
Bladder pain20.02.02.001---
Blood lactate dehydrogenase increased13.04.02.002--
Blood urea increased13.13.01.006---
Blood uric acid increased13.02.04.001---
Body temperature increased13.15.01.001---
Bronchitis11.01.09.001; 22.07.01.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Cheilitis07.05.01.001; 23.03.03.025--
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