Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Reboxetine
Drug ID BADD_D01919
Description Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. Reboxetine has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.
Indications and Usage For the treatment of clinical depression.
Marketing Status approved; experimental
ATC Code N06AX18
DrugBank ID DB00234
KEGG ID D08472
MeSH ID D000077593
PubChem ID 127151
TTD Drug ID D0N8FQ
NDC Product Code Not Available
UNII 947S0YZ36I
Synonyms Reboxetine | Reboxetine Mesylate | 2-((2-Ethoxyphenoxy)benzyl)morpholine methanesulfonate | Vestra
Chemical Information
Molecular Formula C19H23NO3
CAS Registry Number 71620-89-8
SMILES CCOC1=CC=CC=C1OC(C2CNCCO2)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Accommodation disorder06.02.04.001---
Agitation17.02.05.012; 19.06.02.001--
Akathisia17.01.02.002; 19.06.02.006--
Alanine aminotransferase increased13.03.04.005--
Albuminuria20.02.01.001---
Amenorrhoea05.05.01.002; 21.01.02.001--
Anaemia01.03.02.001--
Anorectal disorder07.03.01.001---
Anorgasmia19.08.01.001--
Anxiety19.06.02.002--
Aphasia17.02.03.001; 19.21.01.001--
Asthenia08.01.01.001---
Blood creatinine increased13.13.01.004--
Blood pressure fluctuation24.06.01.002---
Blood pressure systolic increased13.14.03.006---
Blood uric acid increased13.02.04.001---
Body temperature increased13.15.01.001---
Bradycardia02.03.02.002---
Breath odour07.01.06.002---
Bronchitis11.01.09.001; 22.07.01.001--
Cerebral ischaemia17.08.01.005; 24.04.06.003--
Cheilitis07.05.01.001; 23.03.03.025--
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Chills08.01.09.001; 15.05.03.016--
Conduction disorder02.03.01.008--
Confusional state17.02.03.005; 19.13.01.001--
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Coordination abnormal17.02.02.004---
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