Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Quinapril
Drug ID BADD_D01890
Description Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.[A184844] Quinapril was granted FDA approval on 19 November 1991.[L8420] A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.[L8423]
Indications and Usage Quinapril is indicated for the treatment of hypertension and as an adjunct therapy in the treatment of heart failure.[L8420] Quinapril in combination with hydrochlorothiazide is indicated for the treatment of hypertension.[L8423]
Marketing Status approved; investigational
ATC Code C09AA06
DrugBank ID DB00881
KEGG ID D03752
MeSH ID D000077583
PubChem ID 54892
TTD Drug ID D0I7SZ
NDC Product Code 50090-5165; 68001-260; 50090-5400; 68084-899; 69097-841; 71335-1262; 57297-555; 69097-839; 71335-1134; 71335-1441; 43547-412; 68180-557; 70934-964; 68001-189; 69097-843; 71205-635; 63187-425; 63629-8710; 68001-188; 71205-484; 68001-187; 68180-554; 68180-556; 71335-1707; 51655-737; 68180-558; 69097-842; 43547-411; 43547-413
UNII RJ84Y44811
Synonyms Quinapril | 2-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid | Accupril | CI 906 | CI-906 | Quinapril Hydrochloride | PD 109452-2 | PD 109452 2 | PD 1094522 | PD-109,452-2 | PD 109,452 2
Chemical Information
Molecular Formula C25H30N2O5
CAS Registry Number 85441-61-8
SMILES CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC=CC=C3CC2C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001---
Alopecia23.02.02.001--
Amblyopia06.02.01.001---
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Arthralgia15.01.02.001--
Back pain15.03.04.005--
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006---
Cardiac failure02.05.01.001--
Cardiogenic shock02.05.01.003; 24.06.02.006---
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Constipation07.02.02.001--
Cough22.02.03.001--
Depression19.15.01.001--
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Dermatomyositis10.04.04.027; 15.05.01.002; 23.03.02.001---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Drug ineffective08.06.01.006---
Dry mouth07.06.01.002--
Dry throat07.06.01.005; 22.12.03.005---
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Eosinophilic pneumonia01.02.04.003; 22.01.01.004---
Erythema23.03.06.001---
Fatigue08.01.01.002--
Flatulence07.01.04.002--
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ADReCS-Target
Drug Name ADR Term Target
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