Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Propofol
Drug ID BADD_D01864
Description Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
Indications and Usage Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
Marketing Status approved; investigational; vet_approved
ATC Code N01AX10
DrugBank ID DB00818
KEGG ID D00549
MeSH ID D015742
PubChem ID 4943
TTD Drug ID D0A3HB
NDC Product Code 52133-0023; 66064-1015; 14593-885; 63323-269; 0069-0209; 0069-0234; 23155-345; 25021-608; 65219-800; 70518-3256; 69135-0010; 0641-6195; 44657-0044; 16714-528; 51662-1293; 51662-1470; 72572-601; 0641-6196; 72572-590; 0641-6194; 0069-0248; 58032-2019; 0409-4699; 0409-6010; 0591-2136; 16714-977; 72572-612; 16714-690; 51662-1471; 51504-0003
UNII YI7VU623SF
Synonyms Propofol | 2,6-Diisopropylphenol | 2,6 Diisopropylphenol | 2,6-Bis(1-methylethyl)phenol | Disoprofol | Diprivan | Disoprivan | Fresofol | ICI-35,868 | ICI 35,868 | ICI35,868 | ICI-35868 | ICI 35868 | ICI35868 | Ivofol | Propofol Fresenius | Propofol MCT | Propofol Rovi | Propofol-Lipuro | Recofol | Aquafol | Propofol Abbott
Chemical Information
Molecular Formula C12H18O
CAS Registry Number 2078-54-8
SMILES CC(C)C1=C(C(=CC=C1)C(C)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ventricular fibrillation02.03.04.0080.000625%
Ventricular tachycardia02.03.04.0100.001197%
Visual impairment06.02.10.013---
Vomiting07.01.07.003--
Wheezing22.03.01.0090.000625%
Mental status changes19.07.01.0010.000357%-
Brain oedema12.01.10.010; 17.07.02.0030.000268%
Tachyarrhythmia02.03.02.0080.000357%-
Left ventricular dysfunction02.04.02.0110.000179%
Bradyarrhythmia02.03.02.0150.000393%-
Airway complication of anaesthesia12.02.20.001; 22.02.07.006---
Ventricular hypokinesia02.04.02.0130.000179%-
Unwanted awareness during anaesthesia12.02.20.010---
Tonic clonic movements17.12.03.0060.001286%-
Systemic inflammatory response syndrome08.01.05.005; 10.02.01.008; 24.06.03.0080.000179%-
Injection site discolouration08.02.03.038; 12.07.03.038; 23.03.03.046---
Acute coronary syndrome02.02.02.015; 24.04.04.011---
Conjunctival hyperaemia06.04.01.004---
Haemodynamic instability24.03.02.0060.001340%-
Musculoskeletal stiffness15.03.05.027---
Musculoskeletal discomfort15.03.04.001---
Affect lability19.04.01.001---
Myoclonic epilepsy17.12.03.0070.000179%-
Foetal death08.04.01.011; 18.01.02.0030.000179%
Haemorrhage24.07.01.002---
Metabolic disorder14.11.01.0010.000268%-
Pulseless electrical activity02.03.04.0200.001679%-
Nuchal rigidity15.05.04.005; 17.05.02.006---
Muscle relaxant therapy25.16.01.001---
Ventricular dysfunction02.04.02.005---
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