Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Proguanil
Drug ID BADD_D01853
Description Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, _Plasmodium falciparum_ and _Plasmodium vivax_, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Indications and Usage For the causal prevention and suppression of malaria caused by susceptible strains of P. falciparum and other species of Plasmodium found in some geographical areas of the world.
Marketing Status approved
ATC Code P01BB01
DrugBank ID DB01131
KEGG ID D08428
MeSH ID D002727
PubChem ID 6178111
TTD Drug ID D0P8RS
NDC Product Code 65977-0071
UNII S61K3P7B2V
Synonyms Proguanil | Chlorguanid | Chloroguanide | Proguanil Hydrochloride | Hydrochloride, Proguanil | Chloroguanide Hydrochloride | Hydrochloride, Chloroguanide | Paludrine | Paludrin | Bigumal | Chloriguane
Chemical Information
Molecular Formula C11H16ClN5
CAS Registry Number 500-92-5
SMILES CC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Amylase increased13.05.01.009--
Body temperature increased13.15.01.001---
Cough22.02.03.001--
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Erythema23.03.06.001---
Gastrointestinal disorder07.11.01.001---
Gastrointestinal pain07.01.05.005--
Hallucination19.10.04.003--
Headache17.14.01.001--
Immune system disorder10.02.01.001---
Nausea07.01.07.001--
Nervous system disorder17.02.10.001---
Pancytopenia01.03.03.003---
Rash23.03.13.001---
Skin disorder23.03.03.007---
Stomatitis07.05.06.005--
Vomiting07.01.07.003--
Lymphatic disorder01.09.01.003---
Hepatic enzyme increased13.03.04.028---
Malnutrition14.03.02.004---
Mediastinal disorder22.09.03.001---
Mental disorder19.07.01.002---
Decreased appetite08.01.09.028; 14.03.01.005--
Blood disorder01.05.01.004---
Hepatobiliary disease09.01.08.003---
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