ADReCS

Pharmaceutical Information

Drug Name	Prednisolone
Drug ID	BADD_D01831
Description	Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.[A187463] Prednisolone was granted FDA approval on 21 June 1955.[L9431]
Indications and Usage	Prednisolone is indicated to treat endocrine, rheumatic, and hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, and gastrointestinal diseases; allergic and edematous states; and other conditions like tuberculous meningitis.[L9542]
Marketing Status	approved; vet_approved
ATC Code	A01AC04; A07EA01; C05AA04; D07AA03; D07XA02; H02AB06; R01AD02; S01BA04; S01CB02; S02BA03; S03BA02
DrugBank ID	DB00860
KEGG ID	D00472
MeSH ID	D011239
PubChem ID	5755
TTD Drug ID	D0D1SG
NDC Product Code	38779-0150; 64958-0097; 82298-104; 67296-1656; 50383-042; 59651-491; 63187-466; 0527-5406; 65089-0038; 50090-0655; 57582-004; 62135-437; 73534-505; 49452-5980; 82298-105; 82298-106; 60592-911; 60722-3001; 51927-0234; 22552-0052
UNII	9PHQ9Y1OLM
Synonyms	Prednisolone \| Predate \| Predonine \| Di-Adreson-F \| Di Adreson F \| DiAdresonF

Chemical Information

Molecular Formula	C21H28O5
CAS Registry Number	50-24-8
SMILES	CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Photophobia	06.01.01.004; 17.17.02.006	0.000175%
Pica	14.03.02.014; 19.09.01.009	0.000035%		-
Pleural effusion	22.05.02.002	0.000559%
Pleurisy	22.05.01.001	0.000122%		-
Pneumonitis	22.01.01.006	0.000192%
Pneumothorax	22.05.02.003	0.000227%
Poikilocytosis	01.07.02.009	0.000035%		-
Pollakiuria	20.02.02.007	0.000157%
Polydipsia	05.03.03.002; 14.05.02.001	0.000035%		-
Polymyalgia rheumatica	10.04.05.003; 15.06.01.001	0.000122%		-
Polyneuropathy	17.09.03.012	0.000122%		-
Portal vein thrombosis	09.01.06.007; 24.01.03.003	0.000052%
Post herpetic neuralgia	11.07.01.010; 17.02.07.014	0.000035%		-
Pre-eclampsia	18.02.03.002; 20.01.08.002; 24.08.07.002	0.000140%		-
Premature baby	18.04.02.001	0.001084%		-
Premature delivery	18.07.01.006	0.000426%
Premature labour	18.07.01.002	0.000087%		-
Premature separation of placenta	18.02.01.004; 24.07.03.019	0.000035%		-
Priapism	21.03.01.005; 24.04.12.007	0.000035%		-
Prinzmetal angina	02.02.02.019; 24.04.04.015	0.000105%		-
Proctalgia	07.03.02.001	0.000087%
Productive cough	22.02.03.005	0.000217%
Proteinuria	20.02.01.011	0.000280%
Psychomotor hyperactivity	17.01.02.011; 19.11.02.003	0.000329%		-
Psychotic behaviour	19.03.01.003	0.000035%		-
Pulmonary alveolar haemorrhage	22.01.02.005; 24.07.01.015	0.000122%		-
Pulmonary congestion	02.05.02.002; 22.01.03.002; 24.03.08.001	0.000070%		-
Pulmonary embolism	22.06.02.001; 24.01.06.001	0.000786%		-
Pulmonary haemorrhage	22.12.01.009; 24.07.01.016	0.000140%
Pulmonary hypertension	22.06.01.001; 24.08.03.002	0.000122%

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