| Pharmaceutical Information |
| Drug Name |
Prednicarbate |
| Drug ID |
BADD_D01830 |
| Description |
Prednicarbate is a relatively new topical corticosteroid drug that displays a similar potency as [hydrocortisone]. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy. The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin 1-alpha cytokine within keratinocytes. IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and IL-6 synthesis, which are related to skin thickness. |
| Indications and Usage |
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. |
| Marketing Status |
approved; investigational |
| ATC Code |
D07AC18 |
| DrugBank ID |
DB01130
|
| KEGG ID |
D05601
|
| MeSH ID |
C035287
|
| PubChem ID |
52421
|
| TTD Drug ID |
D09IEE
|
| NDC Product Code |
63592-2140; 65089-0032; 52128-168; 0168-0410; 24002-0006 |
| UNII |
V901LV1K7D
|
| Synonyms |
prednicarbate | prednisolone-17-ethylcarbonate-21-propionate | Peitel | HOE 777 | HOE-777 | Batmen | Dermatop |
|
| Chemical Information |
| Molecular Formula |
C27H36O8 |
| CAS Registry Number |
73771-04-7 |
| SMILES |
CCC(=O)OCC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)OC(=O)OCC |
| Chemical Structure |
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| ADRs Induced by Drug |
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