Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Porfimer
Drug ID BADD_D01802
Description The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.
Indications and Usage Indicated in the treatment of esophageal cancer.
Marketing Status approved; investigational
ATC Code L01XD01
DrugBank ID DB00707
KEGG ID D03327
MeSH ID D017323
PubChem ID 135577896
TTD Drug ID D02JDL
NDC Product Code 76128-155
UNII M15H03K69B
Synonyms Dihematoporphyrin Ether | Ether, Dihematoporphyrin | Dihematoporphyrin Ester | Porfimer | DHP Ether | Porfimer Sodium | Photofrin | Photofrin II
Chemical Information
Molecular Formula C68H74N8O11
CAS Registry Number 87806-31-3
SMILES CC1=C(C2=CC3=NC(=CC4=NC(=CC5=C(C(=C(N5)C=C1N2)C(C)O)C)C(=C4C)C(C)OC(C)C6=C(C7=CC 8=C(C(=C(N8)C=C9C(=C(C(=N9)C=C1C(=C(C(=N1)C=C6N7)C)CCC(=O)O)CCC(=O)O)C)C)C(C)O)C )C(=C3CCC(=O)O)C)CCC(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mucosal inflammation08.01.06.002---
Myocardial infarction02.02.02.007; 24.04.04.009--
Nausea07.01.07.001--
Necrosis08.03.03.001; 24.04.02.006---
Neoplasm16.16.02.001---
Nervous system disorder17.02.10.001---
Obesity14.03.02.009--
Odynophagia07.01.06.036---
Oedema08.01.07.006; 14.05.06.010---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Oesophageal carcinoma07.21.06.001; 16.13.06.001---
Oesophageal pain07.01.05.012--
Oesophageal perforation07.04.05.001--
Oesophageal stenosis07.13.02.001--
Oesophageal ulcer07.04.05.002--
Oesophagitis07.08.05.001--
Pain08.01.08.004--
Peritonitis07.19.05.004; 11.01.07.007--
Pharyngitis07.05.07.004; 11.01.13.003; 22.07.03.004--
Photophobia06.01.01.004; 17.17.02.006--
Photosensitivity reaction23.03.09.003--
Pleural effusion22.05.02.002--
Pneumonia11.01.09.003; 22.07.01.003---
Pneumothorax22.05.02.003--
Productive cough22.02.03.005--
Pruritus23.03.12.001--
Pseudoporphyria23.03.01.006---
Pulmonary embolism22.06.02.001; 24.01.06.001---
Pulmonary haemorrhage22.12.01.009; 24.07.01.016--
Pulmonary oedema02.05.02.003; 22.01.03.003--
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