| Drug Name |
Polymyxin b sulfate |
| Drug ID |
BADD_D01795 |
| Description |
Polymyxin B was discovered in the 1940s[A176429]. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes[A176426]. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram-negative cocci, are resistant[A176426]. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of _Pseudomonas aeruginosa_[FDA Label]. Polymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line[A176429]. |
| Indications and Usage |
Polymyxin B is indicated for the treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa[FDA Label]. |
| Marketing Status |
approved; vet_approved |
| ATC Code |
A07AA05; S01AA18; S02AA11; J01XB02; S03AA03 |
| DrugBank ID |
DB00781
|
| KEGG ID |
D01066
|
| MeSH ID |
D011112
|
| PubChem ID |
3083708
|
| TTD Drug ID |
D09OOV
|
| NDC Product Code |
59838-101; 76003-0926; 70860-124; 54147-0006; 65897-1004; 63323-321; 70594-049; 45932-0001; 55500-0008; 70860-103; 51551-0305; 49452-5600; 51927-1086; 72266-249; 51551-0306; 54563-008; 68083-174; 62991-3071; 0143-9941; 38779-0045; 45932-0002; 45932-0018; 51552-0946; 65897-2004; 63323-367; 45932-0017 |
| UNII |
19371312D4
|
| Synonyms |
Polymyxin B | Polymyxin B Sulfate | Aerosporin |
