Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Podofilox
Drug ID BADD_D01790
Description A lignan found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Indications and Usage For treatment of external genital warts (Condyloma acuminatum).
Marketing Status approved
ATC Code D06BB04
DrugBank ID DB01179
KEGG ID D05529
MeSH ID D011034
PubChem ID 10607
TTD Drug ID D0D4HN
NDC Product Code 0574-0611; 63629-8832; 0591-3204; 67430-100; 0023-6118; 66245-001
UNII L36H50F353
Synonyms Podophyllotoxin | Podofilox | Condylox | CPH86 | Epipodophyllotoxin | Podocon-25 | Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer | Podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer | Podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer | Wartec | Warticon | Podofilm | Condyline | Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer
Chemical Information
Molecular Formula C22H22O8
CAS Registry Number 518-28-5
SMILES COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Application site irritation08.02.01.003; 12.07.01.003---
Application site pain08.02.01.004; 12.07.01.004---
Balanoposthitis21.09.03.001---
Blister12.01.06.002; 23.03.01.001---
Burning sensation08.01.09.029; 17.02.06.001---
Dermatitis23.03.04.002---
Dermatitis bullous23.03.01.002--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dry skin23.03.03.001--
Dyspareunia19.08.05.004; 21.03.02.016--
Erythema23.03.06.001---
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemoglobin13.01.05.018---
Headache17.14.01.001--
Immune system disorder10.02.01.001---
Insomnia17.15.03.002; 19.02.01.002--
Instillation site pain08.02.01.008; 12.07.01.008---
Oedema08.01.07.006; 14.05.06.010---
Pain08.01.08.004--
Paraesthesia17.02.06.005; 23.03.03.094--
Phimosis03.03.01.003; 21.12.01.004---
Pruritus23.03.12.001--
Rash23.03.13.001---
Scab23.03.03.004---
Scar12.01.06.008; 23.03.11.008---
Skin discolouration23.03.03.005---
Skin disorder23.03.03.007---
Skin erosion23.07.03.002---
Skin exfoliation23.03.07.003---
Skin odour abnormal23.03.03.012--
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