Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pilocarpine hydrochloride
Drug ID BADD_D01771
Description A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
Indications and Usage For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome. A pilocarpine ophthalmic solution is indicated for the treatment of presbyopia in adults.[L39015]
Marketing Status approved; investigational
ATC Code S01EB01; N07AX01
DrugBank ID DB01085
KEGG ID D02200
MeSH ID D010862
PubChem ID 5909
TTD Drug ID D06HLY
NDC Product Code 0228-2837; 17478-223; 63279-100; 59212-775; 61314-204; 69238-1746; 69292-265; 71335-2094; 38779-0182; 16714-121; 59651-224; 61314-206; 0527-1407; 68084-928; 69238-1747; 12538-1921; 69205-001; 59651-225; 61314-203; 0074-7098; 17478-226; 50268-652; 59212-705; 63629-2099; 0527-1313; 16714-122; 63629-8351; 69238-1745; 82133-200; 17478-224; 0228-2801; 60219-5922
UNII 0WW6D218XJ
Synonyms Pilocarpine | Isoptocarpine | Salagen | Pilocarpine Hydrochloride | Hydrochloride, Pilocarpine | Pilocarpine, Monohydrochloride, (3S-cis)-Isomer | Pilocarpine Nitrate | Nitrate, Pilocarpine | Pilocarpine Mononitrate, (3S-cis)-Isomer | Isopilocarpine | Ocusert
Chemical Information
Molecular Formula C11H17ClN2O2
CAS Registry Number 54-71-7
SMILES CCC1C(COC1=O)CC2=CN=CN2C.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Glossitis07.14.01.001---
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemorrhage intracranial17.08.01.008; 24.07.04.003--
Hallucination, visual19.10.04.007---
Headache17.14.01.0010.115581%
Hepatitis09.01.07.004---
Herpes simplex11.05.02.001; 23.11.05.004---
Hiccups07.01.06.009; 22.12.01.001--
Hyperaemia24.03.02.0020.007577%-
Hyperbilirubinaemia01.06.04.003; 09.01.01.003; 14.11.01.010---
Hyperhidrosis08.01.03.028; 23.02.03.0040.019164%
Hyperkinesia17.01.02.008---
Hypersensitivity10.01.03.0030.012628%
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Hypoglycaemia05.06.03.001; 14.06.03.001--
Hypotension24.06.03.002--
Hypothermia08.05.01.003; 12.05.03.001--
Increased appetite08.01.09.027; 14.03.01.003---
Infection11.01.08.002---
Influenza11.05.03.001; 22.07.02.001---
Injury12.01.08.004---
Insomnia17.15.03.002; 19.02.01.002--
Instillation site pain08.02.01.008; 12.07.01.0080.005051%-
Interstitial lung disease10.02.01.033; 22.01.02.0030.001486%-
Keratitis06.04.02.002--
Laboratory test abnormal13.18.01.001---
Lacrimation disorder06.08.02.010---
Lacrimation increased06.08.02.0040.005794%
Laryngitis11.01.13.001; 22.07.03.001--
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