Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pertuzumab
Drug ID BADD_D01744
Description Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. It was first approved by the FDA in 2012 for use with [docetaxel] and another HER2-targeted monoclonal antibody, [trastuzumab], in the treatment of metastatic HER2-positive breast cancer. Its indicated conditions have since expanded to include use as both a neoadjuvant therapy and an adjuvant therapy in the treatment of HER2-positive breast cancers at high risk of recurrence.[L14642,L14772]
Indications and Usage Pertuzumab is indicated for intravenous administration in combination with [trastuzumab] and [docetaxel] for the treatment of patients with HER2-positive metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease.[L14747] It is also indicated in combination with trastuzumab and other chemotherapies for the neoadjuvant treatment of HER2-positive locally advanced, inflammatory, or early-stage breast cancer as part of a complete treatment regimen[L14747] and as adjuvant treatment in patients with HER2-positive early-stage breast cancer at high risk of recurrence.[L14747] Pertuzumab is also indicated for subcutaneous injection - in combination with trastuzumab and [hyaluronidase] - in the treatment of HER2-positive breast cancers in adults.[L14510]
Marketing Status approved
ATC Code L01FD02
DrugBank ID DB06366
KEGG ID D05446
MeSH ID C485206
PubChem ID Not Available
TTD Drug ID D0CI4E
NDC Product Code 50242-145; 50242-144
UNII K16AIQ8CTM
Synonyms pertuzumab | Perjeta | RG-1273 | rhumab 2C4 | rhumab-2C4 | Omnitarg | Omnitarg, 2C4
Chemical Information
Molecular Formula Not Available
CAS Registry Number 380610-27-5
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Arthralgia15.01.02.001--
Asthenia08.01.01.001---
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dry skin23.03.03.001--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspnoea02.11.05.003; 22.02.01.004--
Fatigue08.01.01.002--
Febrile neutropenia01.02.03.002; 08.05.02.004--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Insomnia17.15.03.002; 19.02.01.002--
Lacrimation increased06.08.02.004--
Leukopenia01.02.02.001---
Mucosal inflammation08.01.06.002---
Myalgia15.05.02.001--
Nail disorder23.02.05.002--
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.001--
Neuropathy peripheral17.09.03.003---
Neutropenia01.02.03.004---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Paronychia11.02.01.054; 23.11.04.006--
Pleural effusion22.05.02.002--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
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