Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Perflutren
Drug ID BADD_D01734
Description Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
Indications and Usage Used as an ultrasound contrast imaging in cardiology and radiology.
Marketing Status approved
ATC Code Not Available
DrugBank ID DB00556
KEGG ID D01738
MeSH ID C042852
PubChem ID 6432
TTD Drug ID D0G5BK
NDC Product Code 71124-0016; 11994-011; 11994-017; 63946-0040; 65044-0040
UNII CK0N3WH0SR
Synonyms perflutren | octafluoropropane | C3F8-gas | perfluoropropane | MRX-115
Chemical Information
Molecular Formula C3F8
CAS Registry Number 76-19-7
SMILES C(C(F)(F)F)(C(F)(F)F)(F)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Contrast media reaction10.01.01.011; 12.02.05.029--
Cough22.02.03.001-
Crying08.01.03.005; 12.02.11.001; 17.02.05.013; 19.04.02.002--
Cyanosis02.11.04.004; 22.02.02.007; 23.06.04.005; 24.03.01.007-
Death08.04.01.001--
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007-
Drug hypersensitivity10.01.01.001---
Dry mouth07.06.01.002--
Dry skin23.03.03.001-
Dry throat07.06.01.005; 22.12.03.005---
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004-
Electrocardiogram abnormal13.14.05.001---
Eosinophilia01.02.04.001--
Erythema23.03.06.001--
Extravasation08.01.03.008--
Eye disorder06.08.03.001---
Eye swelling06.08.03.003---
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.004--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--
Feeling hot08.01.09.009--
Flank pain08.01.08.007; 15.03.04.003; 20.02.03.006-
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002-
Gastrointestinal disorder07.11.01.001---
Gastrointestinal pain07.01.05.005--
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