Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Perampanel
Drug ID BADD_D01733
Description Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and psychiatric reactions in patients taking Fycompa™.
Indications and Usage Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.
Marketing Status approved
ATC Code N03AX22
DrugBank ID DB08883
KEGG ID D08964
MeSH ID C551441
PubChem ID 9924495
TTD Drug ID D0U3ED
NDC Product Code 11071-904; 47848-049; 50379-0020; 60510-609; 62856-280; 11071-906; 62856-276; 69616-274; 69616-278; 69616-280; 62856-272; 69616-282; 11071-907; 60510-604; 60510-608; 11071-902; 60510-606; 69616-290; 67835-0026; 62856-278; 62856-282; 62856-290; 69616-272; 11071-905; 62856-274; 69616-276; 11071-903; 60510-605; 60510-607
UNII H821664NPK
Synonyms perampanel | 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one | perampanel hydrate | perampanel hydrate (4:3) | E-2007 | E2007 | ER-155055-90 | Fycompa
Chemical Information
Molecular Formula C23H15N3O
CAS Registry Number 380917-97-5
SMILES C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mental disorder19.07.01.0020.000311%-
Motor dysfunction15.05.06.006; 17.01.02.0310.000274%-
Partial seizures17.12.03.0100.000125%-
Abnormal behaviour19.01.01.0010.002615%-
Decreased appetite08.01.09.028; 14.03.01.005--
Psychiatric symptom19.01.02.0010.000884%-
Inner ear disorder04.04.02.002---
Psychotic disorder19.03.01.0020.002080%
Sudden unexplained death in epilepsy08.04.01.012; 17.12.03.0190.000436%-
Suicidal behaviour19.12.01.006---
Oropharyngeal pain07.05.05.004; 22.12.03.016--
Drug-induced liver injury09.01.07.023; 12.03.01.0440.000125%-
Atonic seizures17.12.03.0200.000423%-
Drop attacks15.05.04.018; 17.05.02.0160.000274%-
Drowning08.04.01.014; 12.01.18.0030.000125%-
Persecutory delusion19.10.01.0070.000125%-
Violence-related symptom19.05.01.0220.000336%-
Negative thoughts19.15.02.0120.000125%-
Communication disorder19.19.01.0080.000125%-
Seizure cluster17.12.03.0290.000187%-
Gait inability08.01.02.011; 17.02.05.0690.000274%-
Hypersensitivity pneumonitis10.01.03.056; 22.01.01.0270.000187%-
Skin laceration12.01.06.016; 23.03.11.041---
Therapeutic product effect decreased08.06.01.0500.000423%-
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