Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Perampanel
Drug ID BADD_D01733
Description Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and psychiatric reactions in patients taking Fycompa™.
Indications and Usage Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.
Marketing Status approved
ATC Code N03AX22
DrugBank ID DB08883
KEGG ID D08964
MeSH ID C551441
PubChem ID 9924495
TTD Drug ID D0U3ED
NDC Product Code 11071-904; 47848-049; 50379-0020; 60510-609; 62856-280; 11071-906; 62856-276; 69616-274; 69616-278; 69616-280; 62856-272; 69616-282; 11071-907; 60510-604; 60510-608; 11071-902; 60510-606; 69616-290; 67835-0026; 62856-278; 62856-282; 62856-290; 69616-272; 11071-905; 62856-274; 69616-276; 11071-903; 60510-605; 60510-607
UNII H821664NPK
Synonyms perampanel | 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one | perampanel hydrate | perampanel hydrate (4:3) | E-2007 | E2007 | ER-155055-90 | Fycompa
Chemical Information
Molecular Formula C23H15N3O
CAS Registry Number 380917-97-5
SMILES C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Salivary hypersecretion07.06.01.0090.000125%-
Seizure17.12.03.0010.002652%
Somnambulism17.15.02.004; 19.02.03.0060.000274%-
Somnolence17.02.04.006; 19.02.05.0030.003836%
Speech disorder17.02.08.003; 19.19.02.002; 22.12.03.0270.000125%-
Status epilepticus17.12.03.0050.000498%-
Suicidal ideation19.12.01.0030.003748%
Suicide attempt19.12.01.0040.002055%
Tic17.02.05.024; 19.11.04.0010.000423%-
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urinary incontinence17.05.01.008; 20.02.02.0100.000423%
Urinary retention20.02.02.0110.000336%
Urinary tract infection11.01.14.004; 20.08.02.001--
Vertigo04.04.01.003; 17.02.12.002--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
Vulvovaginal discomfort21.08.02.0050.000423%-
Weight increased13.15.01.006--
Homicidal ideation19.05.01.0080.000996%-
Balance disorder08.01.03.081; 17.02.02.0070.000249%-
Contusion12.01.06.001; 15.03.05.007; 23.03.11.002; 24.07.06.001--
Self-injurious ideation19.12.01.0070.000274%-
Musculoskeletal discomfort15.03.04.001---
Affect lability19.04.01.001---
Cognitive disorder17.03.03.003; 19.21.02.0010.000548%
Connective tissue disorder10.04.04.026; 15.06.01.006---
Infestation11.09.01.001; 23.11.01.002---
Limb injury12.01.09.008---
Malnutrition14.03.02.004---
Mediastinal disorder22.09.03.001---
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