Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pentostatin
Drug ID BADD_D01730
Description A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Indications and Usage For the treatment of hairy cell leukaemia refractory to alpha interferon.
Marketing Status Prescription
ATC Code L01XX08
DrugBank ID DB00552
KEGG ID D00155
MeSH ID D015649
PubChem ID 439693
TTD Drug ID D0T3AD
NDC Product Code 14096-124; 42533-109; 59981-005; 0409-0801
Synonyms Pentostatin | Deoxycoformycin | Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)- | 2'-Deoxycoformycin | 2' Deoxycoformycin | NSC-218321 | NSC 218321 | NSC218321 | Co-Vidarabine | CI-825 | CI 825 | CI825 | Nipent
Chemical Information
Molecular Formula C11H16N4O4
CAS Registry Number 53910-25-1
SMILES C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Abscess11.01.08.001--Not Available
Acne23.02.01.001--Not Available
Acute leukaemia01.10.02.001; 16.01.02.001--Not Available
Agitation17.02.05.012; 19.06.02.001--
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Amblyopia06.02.01.001--Not Available
Amenorrhoea05.05.01.002; 21.01.02.001--
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.001--
Angina pectoris02.02.02.002; 24.04.04.002--
Anxiety19.06.02.002--
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Atrioventricular block02.03.01.002--Not Available
Basal cell carcinoma16.03.02.001; 23.08.02.0010.000533%Not Available
Blood creatinine increased13.13.01.004--
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Breast mass21.05.04.002--Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Cardiac arrest02.03.04.001--
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