Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pentamidine isethionate
Drug ID BADD_D01718
Description Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Indications and Usage For the treatment of pneumonia due to Pneumocystis carinii.
Marketing Status approved; investigational
ATC Code P01CX01
DrugBank ID DB00738
KEGG ID D00834
MeSH ID D010419
PubChem ID 8813
TTD Drug ID D05EAM
NDC Product Code 14593-930; 23155-748; 11712-790; 14593-940; 39822-3050; 39822-3030; 63323-113; 11712-788; 13925-515; 63323-877; 13925-522
UNII V2P3K60DA2
Synonyms Pentamidine | Pentamidin | Lomidine | NebuPent | Pentamidine Isethionate | Pentam | Pentamidine Mesylate | Diamidine | Pentacarinat
Chemical Information
Molecular Formula C19H24N4O2.2C2H6O4S
CAS Registry Number 140-64-7
SMILES C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N.C(CS(=O)(=O)O)O.C(CS(=O)(=O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abscess sterile08.01.05.008---
Ageusia07.14.03.003; 17.02.07.001---
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anosmia17.04.04.001; 22.04.03.006--
Anxiety19.06.02.002--
Arrhythmia02.03.02.001---
Arthralgia15.01.02.001--
Asthma10.01.03.010; 22.03.01.002---
Azotaemia20.01.01.001---
Blepharitis06.04.04.001; 23.03.04.012---
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006---
Bronchitis11.01.09.001; 22.07.01.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest discomfort02.02.02.009; 08.01.08.019; 22.12.02.002---
Chills08.01.09.001; 15.05.03.016--
Coagulation time prolonged13.01.02.006---
Confusional state17.02.03.005; 19.13.01.001--
Conjunctivitis06.04.01.002; 11.01.06.012--
Contact lens intolerance06.01.01.003---
Cough22.02.03.001--
Cyanosis02.11.04.004; 22.02.02.007; 23.06.04.005; 24.03.01.007--
Deafness04.02.01.001---
Depression19.15.01.001--
Dermatitis23.03.04.002---
Diabetes mellitus05.06.01.001; 14.06.01.001---
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