| Pharmaceutical Information |
| Drug Name |
Penicillin g sodium |
| Drug ID |
BADD_D01714 |
| Description |
Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms.
Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as *Streptococcus pneumoniae*, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (*S. agalactiae*), *S. viridans*, and *Enterococcus faecalis*. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as *Bacillus anthracis*, *Corynebacterium diphtheriae*, and *Erysipelothrix rhusiopathiae*. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by *Neisseria meningitidis* and *Pasteurella*. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions. |
| Indications and Usage |
For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required such as in the treatment of septicemia, meningitis, pericarditis, endocarditis and severe pneumonia. |
| Marketing Status |
approved; vet_approved |
| ATC Code |
J01CE01; S01AA14 |
| DrugBank ID |
DB01053
|
| KEGG ID |
D02336; D01053
|
| MeSH ID |
D010400
|
| PubChem ID |
23668834
|
| TTD Drug ID |
D0K5OT
|
| NDC Product Code |
0781-6153; 66558-0170 |
| UNII |
YS5LY7JF4N
|
| Synonyms |
Penicillin G | Benzylpenicillin | Coliriocilina | Crystapen | Or-pen | Parcillin | Pekamin | Pengesod | Penibiot | Penicilina G Llorente | Penicillin G Jenapharm | Penicillin G Potassium | Benzylpenicillin Potassium | Penicillin G Sodium | Sodium Penicillin | Sodium Benzylpenicillin | Penicillin Grünenthal | Penilevel | Peniroger | Pfizerpen | Sodiopen | Sodipen | Unicilina | Ursopen | Van-Pen-G | Benpen |
|
| Chemical Information |
| Molecular Formula |
C16H17N2NaO4S |
| CAS Registry Number |
69-57-8 |
| SMILES |
CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.[Na+] |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
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