Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pemetrexed
Drug ID BADD_D01701
Description Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta. It is indicated for use in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are otherwise not candidates for curative surgery. Its use in non-small cell lung cancer has also been investigated.
Indications and Usage Used in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery. Also used as a monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy
Marketing Status approved; investigational
ATC Code L01BA04
DrugBank ID DB00642
KEGG ID D07472
MeSH ID D000068437
PubChem ID 135410875
TTD Drug ID D0Y4GO
NDC Product Code 16729-244; 0338-0722; 0409-0021; 70121-1233; 47848-026; 65129-1366; 55150-383; 0409-3532; 55150-381; 0409-1045; 68001-537; 0409-0020; 0409-1061; 0480-4514; 16729-230; 55150-382; 68001-547; 0480-4515; 0480-4516; 0338-0720; 16729-229; 68001-535; 68001-549; 0409-0004; 0409-2188; 68001-536; 42367-531; 68001-548; 0409-1060; 70121-1232
UNII 04Q9AIZ7NO
Synonyms Pemetrexed | MTA | N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid | Pemetrexed Disodium | Disodium, Pemetrexed | LY 231514 | 231514, LY | LY-231,514 | LY231514 | LY 231,514 | 231,514, LY | LY-231514 | Alimta
Chemical Information
Molecular Formula C20H21N5O6
CAS Registry Number 137281-23-3
SMILES C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Loss of consciousness17.02.04.0040.000336%-
Lung disorder22.02.07.0010.001007%-
Lymphadenopathy01.09.01.0020.000112%-
Mesothelioma16.39.01.001---
Metabolic acidosis14.01.01.0030.000112%-
Metastases to liver09.04.02.004; 16.22.02.001---
Mood altered19.04.02.007---
Mood swings19.04.03.001---
Mouth ulceration07.05.06.0040.000112%-
Mucosal inflammation08.01.06.0020.000560%-
Muscular weakness15.05.06.001; 17.05.03.0050.000246%
Myalgia15.05.02.001--
Myocardial infarction02.02.02.007; 24.04.04.009--
Myocardial ischaemia02.02.02.008; 24.04.04.010---
Nausea07.01.07.001--
Neoplasm malignant16.16.01.001---
Nephropathy20.05.03.0010.000112%-
Nephropathy toxic12.03.01.010; 20.05.03.0020.000224%-
Nervous system disorder17.02.10.001---
Neuritis17.09.03.001---
Neuropathy peripheral17.09.03.0030.000168%-
Neutropenia01.02.03.0040.001343%-
Odynophagia07.01.06.036---
Oedema08.01.07.006; 14.05.06.0100.000336%-
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.0110.000280%
Oesophagitis07.08.05.001--
Pain08.01.08.004--
Pancreatic disorder07.18.02.001---
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.0030.002093%-
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