Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pegaspargase
Drug ID BADD_D01692
Description Pegylated L-asparagine amidohydrolase from E. coli. Pegylation substantially (by a factor of 4) extends the protein half life.
Indications and Usage For treatment of acute lymphoblastic leukemia
Marketing Status approved; investigational
ATC Code L01XX24
DrugBank ID DB00059
KEGG ID D05387
MeSH ID C042705
PubChem ID 436058
TTD Drug ID D0U8JN
NDC Product Code 72694-954
UNII 7D96IR0PPM
Synonyms pegaspargase | pegylated asparaginase | polyethyleneglycol-asparaginase | PEG-asparaginase | pegylated-L-asparaginase | Oncaspar
Chemical Information
Molecular Formula C14H19NO
CAS Registry Number 130167-69-0
SMILES CC1=CC(=C(C=C1)C(=O)C(=C)CN(C)C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alanine aminotransferase increased13.03.04.005--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Aspartate aminotransferase increased13.03.04.011--
Bronchospasm10.01.03.012; 22.03.01.004--
Cerebral haemorrhage17.08.01.003; 24.07.04.001---
Cerebral thrombosis17.08.01.006; 24.01.04.003---
Coagulopathy01.01.02.001---
Death08.04.01.001--
Erythema23.03.06.001---
Hyperbilirubinaemia01.06.04.003; 09.01.01.003; 14.11.01.010---
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Laryngeal oedema10.01.05.003; 22.04.02.001; 23.04.01.005--
Liver function test abnormal13.03.04.030---
Pancreatitis07.18.01.001--
Swelling08.01.03.015---
Systemic lupus erythematosus rash10.04.03.005; 15.06.02.005; 23.03.13.007---
Thrombosis24.01.01.006---
Urticaria10.01.06.001; 23.04.02.001--
Hypofibrinogenaemia01.01.01.010---
Transaminases increased13.03.04.036---
Neutralising antibodies13.06.03.010---
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