Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pegaptanib
Drug ID BADD_D01690
Description Pegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability. Pegaptanib was granted FDA approval on 17 September 2004.[L17903]
Indications and Usage For the treatment of neovascular (wet) age-related macular degeneration.
Marketing Status approved; investigational
ATC Code S01LA03
DrugBank ID DB04895
KEGG ID D05386
MeSH ID C495058
PubChem ID 56603655
TTD Drug ID D0UF9W
NDC Product Code Not Available
UNII 2H1PA8H1EN
Synonyms pegaptanib | Macugen | pegaptanib sodium
Chemical Information
Molecular Formula C22H44N3O10P
CAS Registry Number 222716-86-1
SMILES COCCOC(=O)NCCCCC(C(=O)NCCCCCCCOP(=O)(C)O)NC(=O)OCCOC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Retinal exudates05.07.01.007; 06.10.02.003; 14.07.01.007; 24.03.07.007---
Retinal haemorrhage06.10.01.001; 24.07.05.003---
Retinal oedema06.04.06.007; 24.03.07.006---
Retinal scar06.09.03.017; 12.01.04.021---
Retinal tear06.09.03.010; 12.01.04.014--
Retinal vein occlusion06.10.01.010; 24.01.07.006---
Rhinorrhoea22.12.03.021--
Skin disorder23.03.03.007---
Tenderness08.01.08.005---
Transient ischaemic attack17.08.04.001; 24.04.06.005--
Urinary retention20.02.02.011--
Urinary tract infection11.01.14.004; 20.08.02.001--
Vertigo04.04.01.003; 17.02.12.002--
Vision blurred06.02.06.007; 17.17.01.010--
Visual acuity reduced06.02.10.012; 17.17.01.011--
Visual impairment06.02.10.013---
Vitreous detachment06.09.01.002; 12.01.04.005---
Vitreous disorder06.08.03.006---
Vitreous floaters06.09.01.005--
Vitreous haemorrhage06.10.03.001; 24.07.05.005--
Vitreous opacities06.09.01.007---
Vitreous prolapse06.09.01.009; 12.01.04.022---
Vomiting07.01.07.003--
Hypoacusis04.02.01.006--
Carotid artery occlusion17.08.01.012; 24.04.06.008---
Contusion12.01.06.001; 15.03.05.007; 23.03.11.002; 24.07.06.001--
Conjunctival hyperaemia06.04.01.004---
Eyelids pruritus06.08.03.007; 23.03.12.005---
Eye pruritus06.04.05.006---
Ocular discomfort06.08.03.008---
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