Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pegaptanib
Drug ID BADD_D01690
Description Pegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability. Pegaptanib was granted FDA approval on 17 September 2004.[L17903]
Indications and Usage For the treatment of neovascular (wet) age-related macular degeneration.
Marketing Status approved; investigational
ATC Code S01LA03
DrugBank ID DB04895
KEGG ID D05386
MeSH ID C495058
PubChem ID 56603655
TTD Drug ID D0UF9W
NDC Product Code Not Available
UNII 2H1PA8H1EN
Synonyms pegaptanib | Macugen | pegaptanib sodium
Chemical Information
Molecular Formula C22H44N3O10P
CAS Registry Number 222716-86-1
SMILES COCCOC(=O)NCCCCC(C(=O)NCCCCCCCOP(=O)(C)O)NC(=O)OCCOC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intraocular pressure increased13.07.04.002---
Iridocyclitis06.04.03.001---
Iritis06.04.03.002; 10.02.01.022---
Keratitis06.04.02.002--
Lacrimation increased06.08.02.004--
Macular degeneration06.09.03.001---
Meibomianitis06.04.04.008---
Meniere's disease04.04.02.003; 07.01.07.007; 17.02.12.003---
Mydriasis06.05.03.004; 17.02.11.003---
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.001--
Nervous system disorder17.02.10.001---
Night sweats08.01.03.031; 23.02.03.006---
Nightmare19.02.03.003---
Ocular hyperaemia06.04.05.004---
Ocular hypertension06.03.01.003---
Optic nerve cupping06.09.02.003---
Palpitations02.11.04.012--
Panophthalmitis06.04.05.005---
Periorbital haematoma06.07.02.004; 12.01.04.013; 23.03.11.001; 24.07.05.008---
Photophobia06.01.01.004; 17.17.02.006--
Photopsia06.02.06.004; 17.17.01.006--
Pleural effusion22.05.02.002--
Pruritus23.03.12.001--
Punctate keratitis06.04.02.003---
Pupillary disorder06.05.03.008; 17.02.11.006---
Pupillary reflex impaired06.05.03.009; 17.02.11.007---
Rash23.03.13.001---
Retinal artery occlusion06.10.01.005; 24.01.07.003---
Retinal detachment06.09.03.003; 12.01.04.004--
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