Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Panitumumab
Drug ID BADD_D01666
Description Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent. Panitumumab was granted FDA approval on 27 September 2006.[L17663]
Indications and Usage For the treatment of EGFR-expressing, metastatic colorectal carcinoma that is refractory to fluoropyrimidine-, oxaliplatin-, and irinotecan- containing chemotherapy regimens.
Marketing Status approved; investigational
ATC Code L01FE02
DrugBank ID DB01269
KEGG ID D05350
MeSH ID D000077544
PubChem ID Not Available
TTD Drug ID D0HU9H
NDC Product Code 55513-956; 55513-954
UNII 6A901E312A
Synonyms Panitumumab | Panitumumab Antibody, Human | Human Panitumumab Antibody | ABX-EGF MAb | ABX-EGF Monoclonal Antibody | ABX EGF Monoclonal Antibody | Monoclonal Antibody, ABX-EGF | Vectibix
Chemical Information
Molecular Formula Not Available
CAS Registry Number 339177-26-3
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abscess11.01.08.001---
Acne23.02.01.001---
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Chills08.01.09.001; 15.05.03.016--
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Cough22.02.03.001--
Death08.04.01.001--
Dermatitis acneiform23.02.01.004--
Dermatitis allergic10.01.03.014; 23.03.04.003---
Diarrhoea07.02.01.001--
Dry skin23.03.03.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Erythema23.03.06.001---
Eye disorder06.08.03.001---
Eye irritation06.04.05.003---
Fatigue08.01.01.002--
Hair disorder23.02.06.003---
Hypersensitivity10.01.03.003--
Hypomagnesaemia14.04.02.001--
Keratitis06.04.02.002--
Lacrimation increased06.08.02.004--
Mucosal inflammation08.01.06.002---
Nail disorder23.02.05.002--
Nausea07.01.07.001--
Necrotising fasciitis11.01.17.002; 15.03.03.004---
Ocular hyperaemia06.04.05.004---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
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