| Drug Name |
Nystatin |
| Drug ID |
BADD_D01591 |
| Description |
Nystatin is a polyene antifungal drug that has broad-spectrum fungicidal and fungistatic activity against a number of yeasts and fungi, most notably _Candida_ species.[L10686] It is one of the most effective antifungal agents synthesized by bacteria, in this case a strain of _Streptomyces noursei_,[L10776] and is closely related to [amphotericin B], differing only slightly in structure.[A188562] Nystatin has a greater antifungal activity than amphotericin B - parenterally administered nystatin, however, is associated with significant toxicity and is not available in a formulation appropriate for systemic use.[A188562] As it undergoes very little absorption following oral or topical administration, nystatin's efficacy is limited to the treatment/prevention of cutaneous, mucocutaneous, and gastrointestinal fungal infections.[L10686,L10728] |
| Indications and Usage |
Nystatin is available in oral formulations for the treatment and/or prevention of oral candidiasis (a.k.a. thrush), intestinal candidiasis, and anal candidiasis.[L10686,L10728] It is indicated topically for the treatment of vulvovaginal candidiasis and other cutaneous candida infections.[L10728] A combination product containing nystatin alongside [neomycin], [gramicidin D], and [triamcinolone] (Viaderm K.C.®) is indicated in the treatment of corticosteroid-responsive dermatoses caused by bacterial or candidal infections and for pruritus ani/vulvae.[L10731] It is also available in combination with [metronidazole] for the treatment of mixed infections due to _Trichomonas vaginalis_ and _Candida albicans_.[L10776]
Nystatin is also sometimes used off-label for the prevention of invasive candidiasis in low birth weight neonates,[A188565] though it is generally reserved as a second-line option after [fluconazole]. |
| Marketing Status |
approved; vet_approved |
| ATC Code |
A07AA02; D01AA01; G01AA01 |
| DrugBank ID |
DB00646
|
| KEGG ID |
D00202
|
| MeSH ID |
D009761
|
| PubChem ID |
11286230
|
| TTD Drug ID |
D08XAC
|
| NDC Product Code |
61813-701; 76003-9999; 17856-1008; 45802-059; 68071-2621; 68308-152; 65415-1372; 0121-0810; 55154-1578; 63187-422; 63629-8694; 63629-8697; 68071-2556; 71205-106; 71205-575; 72189-408; 75834-235; 43386-530; 68382-370; 70518-3284; 63629-2493; 63629-2515; 68788-6792; 68788-8436; 70166-331; 0574-2008; 0832-0465; 65415-1371; 23155-051; 55154-5788; 63187-464; 63187-847; 63629-8521; 63629-8695; 63629-8698; 73141-221; 0093-0983; 38779-0242; 0904-7276; 62991-2785; 13668-595; 50090-2854; 50090-5845; 53002-9380; 63629-2492; 63629-2516; 63629-8519; 66689-008; 68071-2819; 51927-0095; 53734-336; 61813-702; 61813-802; 33342-481; 0121-0868; 42291-651; 45802-048; 53489-400; 63629-8520; 68788-9516; 16714-769; 33342-469; 39822-3015; 50090-2763; 51672-4117; 63629-8350; 63629-8696; 67296-1519; 72189-278; 0168-0007; 50090-3772; 51672-1289; 63187-703; 66689-037; 67296-1860; 68071-2887; 68094-599; 69315-306; 69315-307; 69315-504; 70771-1357; 70771-1585; 72578-089; 61813-801; 0121-4810; 50090-5315; 63739-160; 68788-7949; 0472-0166; 51552-0041; 76003-0827; 0168-0054; 50090-1740; 53002-8220; 55154-4056 |
| UNII |
BDF1O1C72E
|
| Synonyms |
Nystatin | Fungicidin | Mycostatin | Stamicin | Nystatin A1 | Nystatin A2 | Nystatin A3 | Nystatin G | Stamycin | Nilstat |
