Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nortriptyline
Drug ID BADD_D01588
Description Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant (TCA).[L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881]
Indications and Usage Nortriptyline is indicated for the relief of the symptoms of major depressive disorder (MDD).[L11878] Some off-label uses for this drug include treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome.[A191083,L11878]
Marketing Status approved
ATC Code N06AA10
DrugBank ID DB00540
KEGG ID D08288
MeSH ID D009661
PubChem ID 4543
TTD Drug ID D04WFD
NDC Product Code Not Available
UNII BL03SY4LXB
Synonyms Nortriptyline | Desitriptyline | Desmethylamitriptylin | Allegron | Apo-Nortriptyline | Apo Nortriptyline | Aventyl | Gen-Nortriptyline | Gen Nortriptyline | Paxtibi | Nortrilen | Nortriptyline Hydrochloride | Hydrochloride, Nortriptyline | Novo-Nortriptyline | Novo Nortriptyline | Nu-Nortriptyline | Nu Nortriptyline | Pamelor | PMS-Nortriptyline | PMS Nortriptyline | ratio-Nortriptyline | ratio Nortriptyline | Norfenazin
Chemical Information
Molecular Formula C19H21N
CAS Registry Number 72-69-5
SMILES CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Yellow skin08.01.03.046; 09.01.01.009; 23.03.03.042---
Peripheral swelling02.05.04.015; 08.01.03.053---
Balance disorder08.01.03.081; 17.02.02.007---
Acute coronary syndrome02.02.02.015; 24.04.04.011---
Inappropriate antidiuretic hormone secretion05.03.03.001; 14.05.07.001---
Pulseless electrical activity02.03.04.0200.000119%-
Disturbance in sexual arousal19.08.04.003---
Hot flush08.01.03.027; 21.02.02.001; 24.03.01.005--
Decreased appetite08.01.09.028; 14.03.01.005--
Erectile dysfunction19.08.04.001; 21.03.01.007--
Ill-defined disorder08.01.03.049---
Psychotic disorder19.03.01.002--
Bone marrow failure01.03.03.005--
Oropharyngeal discomfort07.05.05.008; 22.12.03.015---
Oropharyngeal pain07.05.05.004; 22.12.03.016--
Drug ineffective for unapproved indication08.06.01.038; 12.09.02.0020.000605%-
Reduced facial expression17.01.05.016; 19.01.02.021---
Suspected suicide08.04.01.017; 19.12.01.0090.000237%-
Therapeutic product effect incomplete08.06.01.052---
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene