Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nitrous oxide
Drug ID BADD_D01580
Description Nitrous oxide, commonly known as "laughing gas", is a chemical compound with the chemical formula N2O. At room temperature, it is a colorless non-flammable gas, with a pleasant, slightly sweet odor and taste. It is used in surgery and dentistry for its anesthetic and analgesic effects. It is known as "laughing gas" due to the euphoric effects of inhaling it, a property that has led to its recreational use as an inhalant drug.
Indications and Usage Not Available
Marketing Status approved; vet_approved
ATC Code N01AX13
DrugBank ID DB06690
KEGG ID D00102
MeSH ID D009609
PubChem ID 948
TTD Drug ID D0O8DI
NDC Product Code 12121-002; 21220-122; 42602-003; 51486-007; 55037-301; 55404-002; 72343-001; 10736-017; 33335-003; 44076-012; 46123-007; 12213-593; 18482-002; 20703-003; 34057-010; 10014-003; 46123-006; 53440-003; 63978-201; 24312-003; 48273-002; 49575-003; 54218-800; 62273-005; 67477-002; 17575-011; 43621-003; 55050-0018; 70151-004; 44517-020; 50554-005; 62097-0004; 67525-400; 10167-200; 11054-007; 46362-003; 52086-015; 62045-8333; 72276-002; 10252-003; 52568-002; 53511-003; 54260-001; 59579-004
UNII K50XQU1029
Synonyms Nitrous Oxide | Oxide, Nitrous | Laughing Gas | Gas, Laughing | Nitrogen Protoxide
Chemical Information
Molecular Formula N2O
CAS Registry Number 10024-97-2
SMILES [N-]=[N+]=O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Thrombocytopenia01.08.01.002---
Tremor17.01.06.0020.000268%
Vertigo04.04.01.003; 17.02.12.0020.000179%
Vitamin B12 deficiency14.12.02.0040.002233%-
Vomiting07.01.07.003--
Quadriparesis17.01.04.0120.000179%-
Balance disorder08.01.03.081; 17.02.02.0070.000179%-
Pneumomediastinum22.09.03.0040.000357%-
Peripheral sensorimotor neuropathy17.09.03.0090.000357%-
Cognitive disorder17.03.03.003; 19.21.02.0010.000357%
Metabolic disorder14.11.01.0010.000179%-
Motor dysfunction15.05.06.006; 17.01.02.0310.000268%-
Central nervous system stimulation25.04.01.001---
Demyelinating polyneuropathy10.04.10.007; 17.09.04.0030.000357%-
Psychotic disorder19.03.01.0020.000179%
Arterial occlusive disease24.04.02.0210.000179%-
Bone marrow failure01.03.03.005--
Substance abuse19.07.06.0180.000714%-
Vascular resistance pulmonary increased13.14.03.020---
Occupational exposure to product12.03.06.001---
Subacute combined cord degeneration01.03.01.007; 14.12.02.011; 17.10.01.0210.004376%-
Hyperhomocysteinaemia01.01.02.021; 14.10.02.0030.000447%-
Choroidal infarction06.10.03.003; 24.04.09.0100.000357%-
Acute polyneuropathy17.09.01.0030.000268%-
Substance dependence19.07.06.0190.000447%-
Axonal and demyelinating polyneuropathy10.04.10.019; 11.07.01.019; 17.09.03.0250.000179%-
Behaviour disorder19.01.01.0050.000179%-
Drug use disorder19.07.06.0120.001429%-
Substance use disorder19.07.06.0200.000179%-
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