| Drug Name |
Nitrofurantoin (macrocrystals) |
| Drug ID |
BADD_D01577 |
| Description |
Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections.[L6856,L6859,L6862] Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein.[A179824] This drug is more resistant to the development of bacterial resistance because it acts on many targets at once.[A179824] Nitrofurantoin is a second line treatment to [trimethoprim]/[sulfamethoxazole].[A179830]
Nitrofurantoin was granted FDA approval on 6 February 1953.[L6895] |
| Indications and Usage |
Nitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.[L6856,L6859,L6862] |
| Marketing Status |
approved; vet_approved |
| ATC Code |
J01XE01 |
| DrugBank ID |
DB00698
|
| KEGG ID |
D00439
|
| MeSH ID |
D009582
|
| PubChem ID |
6604200
|
| TTD Drug ID |
D0R0BX
|
| NDC Product Code |
59651-795; 59651-753 |
| UNII |
927AH8112L
|
| Synonyms |
Nitrofurantoin | Furadoine | Nitrofurantoin, Monohydrate | Furantoin | Macrodantin | Nitrofurantoin Sodium Salt | Furadantin | Furadantine | Furadonine |
