| Pharmaceutical Information |
| Drug Name |
Nitrofurantoin |
| Drug ID |
BADD_D01576 |
| Description |
Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections.[L6856,L6859,L6862] Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein.[A179824] This drug is more resistant to the development of bacterial resistance because it acts on many targets at once.[A179824] Nitrofurantoin is a second line treatment to [trimethoprim]/[sulfamethoxazole].[A179830]
Nitrofurantoin was granted FDA approval on 6 February 1953.[L6895] |
| Indications and Usage |
Nitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.[L6856,L6859,L6862] |
| Marketing Status |
approved; vet_approved |
| ATC Code |
J01XE01 |
| DrugBank ID |
DB00698
|
| KEGG ID |
D00439
|
| MeSH ID |
D009582
|
| PubChem ID |
6604200
|
| TTD Drug ID |
D0R0BX
|
| NDC Product Code |
0591-3685; 48087-0009; 62332-390; 62332-391; 70954-496; 72189-179; 48087-0029; 51927-5024; 46708-390; 67296-1442; 70408-239; 71205-370; 48087-0097; 48087-0148; 68071-2281; 68788-8258; 63629-2464; 65162-689; 0591-3684; 46708-391; 68071-2928; 0472-1992; 70199-036; 70518-3717; 71205-365; 48087-0081; 48087-0147; 13811-719; 71205-852; 48087-0146; 60862-006; 40032-450; 60687-483; 68071-2956; 71335-0878; 59651-206; 61919-458; 62332-389; 71052-240; 16571-888; 64980-593; 16571-740; 43386-450; 46708-389; 60687-472; 68001-423; 70199-006; 0591-3686 |
| UNII |
927AH8112L
|
| Synonyms |
Nitrofurantoin | Furadoine | Nitrofurantoin, Monohydrate | Furantoin | Macrodantin | Nitrofurantoin Sodium Salt | Furadantin | Furadantine | Furadonine |
|
| Chemical Information |
| Molecular Formula |
C8H6N4O5 |
| CAS Registry Number |
67-20-9 |
| SMILES |
C1C(=O)NC(=O)N1N=CC2=CC=C(O2)[N+](=O)[O-] |
| Chemical Structure |
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| ADRs Induced by Drug |
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