Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Nitrofurantoin
Drug ID BADD_D01576
Description Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections.[L6856,L6859,L6862] Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein.[A179824] This drug is more resistant to the development of bacterial resistance because it acts on many targets at once.[A179824] Nitrofurantoin is a second line treatment to [trimethoprim]/[sulfamethoxazole].[A179830] Nitrofurantoin was granted FDA approval on 6 February 1953.[L6895]
Indications and Usage Nitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.[L6856,L6859,L6862]
Marketing Status approved; vet_approved
ATC Code J01XE01
DrugBank ID DB00698
KEGG ID D00439
MeSH ID D009582
PubChem ID 6604200
TTD Drug ID D0R0BX
NDC Product Code 0591-3685; 48087-0009; 62332-390; 62332-391; 70954-496; 72189-179; 48087-0029; 51927-5024; 46708-390; 67296-1442; 70408-239; 71205-370; 48087-0097; 48087-0148; 68071-2281; 68788-8258; 63629-2464; 65162-689; 0591-3684; 46708-391; 68071-2928; 0472-1992; 70199-036; 70518-3717; 71205-365; 48087-0081; 48087-0147; 13811-719; 71205-852; 48087-0146; 60862-006; 40032-450; 60687-483; 68071-2956; 71335-0878; 59651-206; 61919-458; 62332-389; 71052-240; 16571-888; 64980-593; 16571-740; 43386-450; 46708-389; 60687-472; 68001-423; 70199-006; 0591-3686
UNII 927AH8112L
Synonyms Nitrofurantoin | Furadoine | Nitrofurantoin, Monohydrate | Furantoin | Macrodantin | Nitrofurantoin Sodium Salt | Furadantin | Furadantine | Furadonine
Chemical Information
Molecular Formula C8H6N4O5
CAS Registry Number 67-20-9
SMILES C1C(=O)NC(=O)N1N=CC2=CC=C(O2)[N+](=O)[O-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tremor17.01.06.002--
Urticaria10.01.06.001; 23.04.02.0010.000121%
Vasculitis10.02.02.006; 24.12.04.027--
Vertigo04.04.01.003; 17.02.12.002--
Vestibular disorder04.04.02.001; 17.02.02.008--
Vomiting07.01.07.0030.000055%
Wheezing22.03.01.009--
Yellow skin08.01.03.046; 09.01.01.009; 23.03.03.042---
Hypoacusis04.02.01.006--
Balance disorder08.01.03.081; 17.02.02.007---
Blood phosphorus increased13.11.01.016---
Lupus-like syndrome10.04.03.003; 15.06.02.004; 23.03.02.004---
Cardiopulmonary failure02.05.01.004; 22.02.06.004---
Systemic inflammatory response syndrome08.01.05.005; 10.02.01.008; 24.06.03.0080.000055%-
Eye pruritus06.04.05.006---
Musculoskeletal stiffness15.03.05.027---
Musculoskeletal discomfort15.03.04.001---
Drug resistance08.06.01.005---
Electrocardiogram change13.14.05.014---
Limb discomfort15.03.04.014---
Decreased appetite08.01.09.028; 14.03.01.005--
Ill-defined disorder08.01.03.049---
Vitamin B complex deficiency14.12.02.003---
Adverse drug reaction08.06.01.009---
Psychotic disorder19.03.01.002--
Pulmonary toxicity12.03.01.013; 22.01.02.0070.000055%-
Renal impairment20.01.03.010---
Tendon pain15.07.01.009---
Liver injury09.01.07.022; 12.01.17.012---
Oropharyngeal pain07.05.05.004; 22.12.03.016--
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