Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nitric oxide
Drug ID BADD_D01574
Description Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants. Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant. The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.
Indications and Usage For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure
Marketing Status approved
ATC Code R07AX01
DrugBank ID DB00435
KEGG ID D00074
MeSH ID D009569
PubChem ID 145068
TTD Drug ID D0A5FM
NDC Product Code 64693-002; 83202-8251; 72385-001; 72385-002; 80519-301; 83202-2278; 83202-6645; 83202-2149; 83202-5147; 83202-6658; 83202-7712; 83202-1857; 83202-6487; 83202-6518; 83202-6931; 83202-7715; 83202-6841; 64693-003; 83202-2952
UNII 31C4KY9ESH
Synonyms Nitric Oxide | Oxide, Nitric | Nitrogen Monoxide | Monoxide, Nitrogen | Nitric Oxide, Endothelium-Derived | Endothelium-Derived Nitric Oxide | Nitric Oxide, Endothelium Derived | Endogenous Nitrate Vasodilator | Nitrate Vasodilator, Endogenous | Vasodilator, Endogenous Nitrate | Mononitrogen Monoxide | Monoxide, Mononitrogen
Chemical Information
Molecular Formula NO
CAS Registry Number 10102-43-9
SMILES [N]=O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute myocardial infarction02.02.02.001; 24.04.04.001--
Acute respiratory distress syndrome10.02.01.067; 22.01.03.001; 24.03.02.034-
Acute respiratory failure14.01.04.004; 22.02.06.001--
Aortic dissection24.02.03.002--
Atelectasis22.01.02.001--
Bradycardia02.03.02.002--
Cardiac arrest02.03.04.001-
Cardiac failure02.05.01.001-
Cardio-respiratory arrest02.03.04.002; 22.02.06.007--
Cardiogenic shock02.05.01.003; 24.06.02.006--
Cerebral haemorrhage17.08.01.003; 24.07.04.001--
Cerebral infarction17.08.01.004; 24.04.06.002---
Chest discomfort02.02.02.009; 08.01.08.019; 22.12.02.002---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Coagulopathy01.01.02.001--
Condition aggravated08.01.03.004--
Death08.04.01.001-
Death neonatal08.04.01.002; 18.04.01.002-
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dry mouth07.06.01.002-
Dry throat07.06.01.005; 22.12.03.005---
Dyspnoea02.11.05.003; 22.02.01.004--
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009---
Haemoglobin13.01.05.018---
Haemorrhage intracranial17.08.01.008; 24.07.04.003--
Headache17.14.01.001--
Hypotension24.06.03.002-
Hypoxia22.02.02.003-
Interstitial lung disease10.02.01.033; 22.01.02.003--
Intracranial pressure increased17.07.02.002--
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ADReCS-Target
Drug Name ADR Term Target
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