ADReCS

Pharmaceutical Information

Drug Name	Nicotine
Drug ID	BADD_D01564
Description	Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage	For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status	approved
ATC Code	N07BA01
DrugBank ID	DB00184
KEGG ID	D03365
MeSH ID	D009538
PubChem ID	89594
TTD Drug ID	D0T8GD
NDC Product Code	17205-601; 58316-010; 11673-195; 11673-879; 37808-900; 37808-948; 43598-447; 59450-003; 59779-443; 70000-0115; 0536-1107; 70677-0030; 52922-001; 58316-009; 75877-0002; 11822-3627; 11822-4975; 21130-820; 37808-533; 37808-658; 43598-448; 49035-195; 55910-313; 66715-9802; 66715-9805; 66715-9806; 70000-0114; 28663-009; 58316-006; 11673-727; 11673-881; 37808-682; 0135-0196; 37808-711; 37808-739; 49035-196; 53329-192; 59450-002; 60429-443; 60429-445; 62011-0351; 63868-734; 70677-0032; 60429-444; 0363-0455; 0363-0457; 66715-9804; 68016-288; 28663-010; 58316-011; 11822-4973; 37808-753; 43598-446; 0009-5401; 50090-1148; 53329-193; 68016-289; 0536-1108; 58316-008; 29485-5271; 50090-2860; 63981-124; 66715-9803; 68196-194; 0536-1106; 61252-3005; 50090-1697; 59450-001; 63981-190; 70677-0031; 0135-0194; 0135-0195; 49035-782; 49348-788; 50090-2837; 59779-445; 62011-0350; 63868-735; 66715-9801; 68016-290; 69842-828; 50392-101; 55742-003; 11673-971; 11822-4974; 37808-707; 37808-849; 50090-6383; 55741-449; 59779-448; 0363-0451; 62011-0349; 81870-001; 11673-269; 11673-424; 21130-269; 43598-445; 53329-191; 69842-605; 70000-0113; 58316-007; 11673-194; 11673-196; 29485-5270; 37808-383; 37808-911; 49035-194; 0009-5400
UNII	6M3C89ZY6R
Synonyms	Nicotine \| Nicotine Bitartrate \| Nicotine Tartrate

Chemical Information

Molecular Formula	C10H14N2
CAS Registry Number	54-11-5; 22083-74-5
SMILES	CN1CCCC1C2=CN=CC=C2
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Dysstasia	08.01.03.089; 15.03.05.011; 17.02.02.012	-	-	-
Intervertebral disc protrusion	15.10.01.004	0.000940%		-
Musculoskeletal chest pain	15.03.04.012; 22.09.01.001	0.001379%
Necrotising colitis	07.08.01.013	0.000940%		-
Nasal discomfort	22.12.03.012	0.003197%		-
Cardiac flutter	02.03.02.012	-	-	-
Musculoskeletal discomfort	15.03.04.001	-	-	-
Application site swelling	08.02.01.027; 12.07.01.027	0.002445%		-
Affect lability	19.04.01.001	-	-	-
Skin burning sensation	17.02.06.009; 23.03.03.021	0.002445%		-
Foetal death	08.04.01.011; 18.01.02.003	0.000627%
Urine odour abnormal	20.02.01.020	0.002131%		-
Hypoaesthesia oral	07.05.05.003; 17.02.06.021	0.002445%		-
Paraesthesia oral	07.05.05.035; 17.02.06.008	0.001379%		-
Nicotine dependence	19.07.06.017	0.085000%		-
Lung neoplasm malignant	16.19.02.001; 22.08.01.001	0.001881%		-
Adnexa uteri mass	21.07.04.005	0.000940%		-
Application site discolouration	08.02.01.030; 12.07.01.030; 23.03.03.023	0.001379%		-
Application site scar	08.02.01.033; 12.07.01.033; 23.03.11.010	0.000940%		-
Intestinal haemorrhage	07.12.03.005; 24.07.02.031	0.000627%		-
Tobacco withdrawal symptoms	08.06.02.017; 19.07.06.022	-	-	-
Hot flush	08.01.03.027; 21.02.02.001; 24.03.01.005	-	-
General symptom	08.01.03.021	0.000627%		-
Adverse event	08.06.01.010	0.004012%		-
Brain neoplasm	16.30.01.003; 17.20.01.003	0.000627%		-
Cardiac disorder	02.11.01.003	-	-	-
Mediastinal disorder	22.09.03.001	-	-	-
Mental disorder	19.07.01.002	0.001254%		-
Motor dysfunction	15.05.06.006; 17.01.02.031	-	-	-
Temperature regulation disorder	05.03.04.013; 08.05.01.004	0.000627%		-

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