Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Niacin
Drug ID BADD_D01559
Description Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565]
Indications and Usage Niacin is indicated to prevent vitamin deficiencies in pediatric and adult patients receiving parenteral nutrition as part of multivitamin intravenous injections.[L7550,L7553,L7556,L7559] Niacin oral tablets are indicated as a monotherapy or in combination with simvastatin or lovastatin to treat primary hyperlipidemia and mixed dyslipidemia.[L7562,L7565] It can also be used to reduce the risk of nonfatal myocardial infarctions in patients with a history of myocardial infarction and hyperlipidemia.[L7562,L7565] Niacin is also indicated with bile acid binding resins to treat atherosclerosis in patients with coronary artery disease and hyperlipidemia or to treat primary hyperlipidemia.[L7562,L7565] Finally niacin is indicated to treat severe hypertriglyceridemia.[L7562,L7565]
Marketing Status approved; investigational; nutraceutical
ATC Code C04AC01; C10AD02
DrugBank ID DB00627
KEGG ID D00049
MeSH ID D009525
PubChem ID 938
TTD Drug ID Not Available
NDC Product Code 72919-420; 59651-018; 59651-019; 62135-497; 71741-047; 47335-613; 50268-584; 62135-498; 65162-321; 65162-323; 68180-222; 68180-223; 62331-016; 68180-221; 71741-020; 47335-539; 47335-614; 71740-001; 71740-201; 62704-0027; 65162-322; 51552-0559; 62175-322; 33342-189; 59651-020; 62175-320; 25441-0095; 65372-1194; 33342-187; 51407-267; 51407-268
UNII 2679MF687A
Synonyms Niacin | Nicotinic Acid | 3-Pyridinecarboxylic Acid | 3 Pyridinecarboxylic Acid | Niacin Lithium Salt, Hemihydrate | Niacin Potassium Salt | Potassium Salt, Niacin | Niacin Sodium Salt | Sodium Salt, Niacin | Niacin Tartrate | Tartrate, Niacin | Niacin Copper (2+) Salt | Niacin Hydrochloride | Hydrochloride, Niacin | Niacin Iron (2+) Salt | Niacin Tosylate | Tosylate, Niacin | Niacin Zinc Salt | Nicamin | Nico-400 | Nico 400 | Nico400 | Nicobid | Nicocap | Nicolar | Nicotinate | Wampocap | Enduracin | Induracin | Niacin Calcium Salt | Lithium Nicotinate | Nicotinate, Lithium | Niacin Aluminum Salt | Aluminum Salt, Niacin | Niacin Ammonium Salt | Niacin Lithium Salt | Niacin Cobalt (2+) Salt | Niacin Magnesium Salt | Niacin Manganese (2+) Salt
Chemical Information
Molecular Formula C6H5NO2
CAS Registry Number 59-67-6
SMILES C1=CC(=CN=C1)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.0010.000420%
Amylase increased13.05.01.009--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Anxiety19.06.02.0020.000191%
Arrhythmia02.03.02.001---
Asthenia08.01.01.0010.000744%-
Atrial fibrillation02.03.03.002--
Blood bilirubin increased13.03.04.018--
Blood creatine phosphokinase increased13.04.01.001--
Blood glucose increased13.02.02.002---
Blood lactate dehydrogenase increased13.04.02.002--
Blood uric acid increased13.02.04.001---
Burning sensation08.01.09.029; 17.02.06.0010.000420%-
Cough22.02.03.001--
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0070.001163%
Drug hypersensitivity10.01.01.0010.023990%-
Dry skin23.03.03.001--
Dyspnoea02.11.05.003; 22.02.01.0040.001068%
Eructation07.01.02.003--
Erythema23.03.06.0010.001583%-
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.004--
Feeling hot08.01.09.0090.000648%-
Flatulence07.01.04.002--
Flushing08.01.03.025; 23.06.05.003; 24.03.01.0020.006121%
Glucose tolerance decreased13.02.02.004---
Gout14.09.01.001; 15.01.06.001---
Hepatitis09.01.07.0040.000420%-
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