Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Nepafenac
Drug ID BADD_D01555
Description Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.
Indications and Usage For the treatment of pain and inflammation associated with cataract surgery.
Marketing Status approved; investigational
ATC Code S01BC10
DrugBank ID DB06802
KEGG ID D05143
MeSH ID C414203
PubChem ID 151075
TTD Drug ID D02IHW
NDC Product Code 73309-311; 53296-0099; 64181-0019; 42571-353; 58567-104; 86036-006; 0078-0743; 69988-0005; 0078-0778
UNII 0J9L7J6V8C
Synonyms nepafenac | 2-amino-3-benzoylbenzeneacetamide | Nevanac
Chemical Information
Molecular Formula C15H14N2O2
CAS Registry Number 78281-72-8
SMILES C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2N)CC(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Palpitations02.11.04.0120.000794%
Photophobia06.01.01.004; 17.17.02.0060.000647%
Polymenorrhoea21.01.03.003---
Pregnancy18.08.02.004---
Pruritus23.03.12.001--
Punctate keratitis06.04.02.0030.000441%-
Retinal haemorrhage06.10.01.001; 24.07.05.0030.000294%-
Rheumatoid arthritis10.04.06.001; 15.01.03.001---
Scab23.03.03.004---
Scleritis06.04.07.002; 10.02.01.0250.000294%-
Sinusitis11.01.13.005; 22.07.03.007--
Skin disorder23.03.03.007---
Teratogenicity03.02.01.004; 12.03.01.032---
Tinnitus04.04.01.002; 17.04.07.0040.000294%
Urticaria10.01.06.001; 23.04.02.0010.000794%
Vision blurred06.02.06.007; 17.17.01.0100.004029%
Visual acuity reduced06.02.10.012; 17.17.01.0110.001970%
Visual impairment06.02.10.0130.002176%-
Vitreous detachment06.09.01.002; 12.01.04.005---
Vomiting07.01.07.003--
Foreign body sensation in eyes06.01.01.0060.001235%-
Conjunctival hyperaemia06.04.01.0040.000294%-
Sticky skin23.03.03.019---
Eyelid margin crusting06.04.04.005; 23.03.03.0290.001500%-
Eye pruritus06.04.05.0060.001147%-
Ocular discomfort06.08.03.0080.001000%-
Corneal thinning06.06.03.009---
Cystoid macular oedema06.04.06.010; 12.02.02.0050.003293%-
Angiopathy24.03.02.007---
Eyelid disorder06.08.03.010; 23.03.03.028---
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