Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Nepafenac
Drug ID BADD_D01555
Description Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.
Indications and Usage For the treatment of pain and inflammation associated with cataract surgery.
Marketing Status approved; investigational
ATC Code S01BC10
DrugBank ID DB06802
KEGG ID D05143
MeSH ID C414203
PubChem ID 151075
TTD Drug ID D02IHW
NDC Product Code 73309-311; 53296-0099; 64181-0019; 42571-353; 58567-104; 86036-006; 0078-0743; 69988-0005; 0078-0778
UNII 0J9L7J6V8C
Synonyms nepafenac | 2-amino-3-benzoylbenzeneacetamide | Nevanac
Chemical Information
Molecular Formula C15H14N2O2
CAS Registry Number 78281-72-8
SMILES C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2N)CC(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal labour18.07.02.001---
Abnormal sensation in eye06.01.01.0010.000294%-
Arrhythmia02.03.02.0010.000294%-
Arthritis15.01.01.001--
Atrial fibrillation02.03.03.0020.000294%
Bleeding time prolonged13.01.02.002---
Blepharitis06.04.04.001; 23.03.04.012---
Blindness06.02.10.003; 17.17.01.0030.000441%-
Blood pressure increased13.14.03.005---
Cataract06.06.01.0010.000294%
Cerebrovascular accident17.08.01.007; 24.03.05.0010.000294%
Conjunctival oedema06.04.01.0010.000588%-
Conjunctivitis allergic06.04.01.003; 10.01.04.002---
Corneal deposits06.06.03.002---
Corneal epithelium defect06.06.03.0120.000882%-
Corneal erosion06.06.03.0030.001941%-
Corneal infiltrates06.08.01.0020.000588%-
Corneal oedema06.04.02.0010.000794%-
Corneal opacity06.06.03.0050.000735%-
Corneal perforation06.06.03.006; 12.01.04.0030.000588%-
Corneal scar06.06.03.015; 12.01.04.015---
Cutis laxa15.06.01.007; 23.03.02.009---
Dermatitis atopic10.01.04.004; 23.03.04.016---
Diabetes mellitus05.06.01.001; 14.06.01.001---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0070.001088%
Drug ineffective08.06.01.0060.003382%-
Dry eye06.08.02.0010.002941%
Dry mouth07.06.01.002--
Dyspepsia07.01.02.0010.000647%
Endophthalmitis06.04.05.009; 11.01.06.003--
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