Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Neostigmine
Drug ID BADD_D01553
Description A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
Indications and Usage Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.
Marketing Status approved; vet_approved
ATC Code N07AA01; S01EB06
DrugBank ID DB01400
KEGG ID D08261
MeSH ID D009388
PubChem ID 4456
TTD Drug ID D08USJ
NDC Product Code 71872-7178; 43598-528; 43598-529
UNII 3982TWQ96G
Synonyms Neostigmine | Synstigmin | Proserine | Prozerin | Polstigmine | Neostigmine Bromide | Bromide, Neostigmine | Syntostigmine | Neostigmine Methylsulfate | Methylsulfate, Neostigmine | Prostigmine | Prostigmin
Chemical Information
Molecular Formula C12H19N2O2+
CAS Registry Number 59-99-4
SMILES CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Urticaria10.01.06.001; 23.04.02.001--
Vomiting07.01.07.003--
Wheezing22.03.01.009--
Musculoskeletal discomfort15.03.04.001---
Procedural complication12.02.05.005--
Post procedural complication12.02.05.018---
Incision site complication12.02.05.012---
Connective tissue disorder10.04.04.026; 15.06.01.006---
Mediastinal disorder22.09.03.001---
Mental disorder19.07.01.002---
Abnormal behaviour19.01.01.001---
Pulmonary function test decreased13.19.01.001---
Procedural pain08.01.08.009; 12.02.05.007---
Ventricular tachyarrhythmia02.03.04.0120.000269%-
Procedural nausea07.01.07.005; 12.02.03.003---
Stress cardiomyopathy02.04.01.012; 24.04.04.0260.000358%-
Therapeutic product effect decreased08.06.01.0500.000394%-
Therapeutic product effect incomplete08.06.01.0520.000179%-
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ADReCS-Target
Drug Name ADR Term Target
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