Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nebivolol hydrochloride
Drug ID BADD_D01542
Description Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity.[A182579] Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol].[A182579] Nebivolol and other beta blockers are generally not first line therapies as many patients are first treated with thiazide diuretics.[A182594] Nebivolol was granted FDA approval on 17 December 2007.[L7985]
Indications and Usage Nebivolol is indicated to treat hypertension.[A2762,A182579,L7985,L7988]
Marketing Status approved; investigational
ATC Code C07AB12
DrugBank ID DB04861
KEGG ID D06622
MeSH ID D000068577
PubChem ID 9933004
TTD Drug ID D0Z1UA
NDC Product Code 29300-377; 0456-1402; 0456-1420; 0456-1411; 0456-1421; 50370-0012; 66577-024; 29300-378; 50090-1127; 50090-3326; 65691-0062; 69037-0004; 76397-009; 0456-1410; 64220-187; 76397-008; 29300-375; 29300-376; 68462-617; 0456-1403; 0456-1406; 52133-0039; 50090-1307; 68462-618; 68462-615; 68462-616; 0456-1405
UNII JGS34J7L9I
Synonyms Nebivolol | Alpha,Alpha'-(Iminobis(Methylene))bis(6-Fluoro-3,4-dihydro)-2H-1-benzopyran-2-methanol | Bystolic | Nebilet | Silostar | Nebivolol Hydrochloride | Hydrochloride, Nebivolol | R 67555 | 67555, R | R-67555 | R67555 | Lobivon
Chemical Information
Molecular Formula C22H26ClF2NO4
CAS Registry Number 152520-56-4
SMILES C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Peripheral ischaemia24.04.03.002--
Platelet count decreased13.01.04.001--
Pruritus23.03.12.001--
Psoriasis10.02.01.036; 23.03.14.002---
Rash23.03.13.001---
Raynaud's phenomenon24.04.03.003---
Skin disorder23.03.03.007---
Somnolence17.02.04.006; 19.02.05.003--
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Thrombocytopenia01.08.01.002---
Urticaria10.01.06.001; 23.04.02.001--
Vertigo04.04.01.003; 17.02.12.002--
Vomiting07.01.07.003--
Erectile dysfunction19.08.04.001; 21.03.01.007--
Acute kidney injury20.01.03.016--
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