Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nafcillin sodium
Drug ID BADD_D01516
Description A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be used as a first-line therapy in Methicillin-Sensitive *Staphylococcus aureus* infections [A20360].
Indications and Usage Indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
Marketing Status approved; investigational
ATC Code J01CF06
DrugBank ID DB00607
KEGG ID D00928
MeSH ID D009254
PubChem ID 23667630
TTD Drug ID D0A0JH
NDC Product Code 52946-0819; 25021-141; 55150-122; 70860-117; 63323-328; 66558-0202; 55150-124; 63323-327; 52946-0922; 25021-139; 25021-140; 55150-123; 70860-116; 61126-704; 70860-119
UNII 49G3001BCK
Synonyms Nafcillin | Naphthamidopenicillin | Nafcil | Nafcillin Sodium | Sodium, Nafcillin | Nafcillin, Monosodium Salt, Anhydrous | Sodium Nafcillin | Nafcillin, Sodium
Chemical Information
Molecular Formula C21H21N2NaO5S
CAS Registry Number 985-16-0
SMILES CCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.04.011--
Bronchospasm10.01.03.012; 22.03.01.004--
Circulatory collapse24.06.02.001---
Death08.04.01.001--
Diarrhoea07.02.01.001--
Drug hypersensitivity10.01.01.001---
Extravasation08.01.03.008---
Hepatotoxicity09.01.07.009; 12.03.01.008---
Hypotension24.06.03.002--
Laryngospasm22.04.02.002--
Malaise08.01.01.003--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Neurotoxicity12.03.01.011; 17.02.10.002---
Neutropenia01.02.03.004---
Pain08.01.08.004--
Phlebitis12.02.01.002; 24.12.03.004--
Pruritus23.03.12.001--
Pseudomembranous colitis07.19.01.003; 11.02.02.002---
Pyrexia08.05.02.003--
Renal tubular disorder20.05.03.004---
Skin exfoliation23.03.07.003---
Stomatitis07.05.06.005--
Swelling08.01.03.015---
Thrombophlebitis24.01.02.001---
Tongue discolouration07.14.02.006---
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