Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Nadolol
Drug ID BADD_D01512
Description Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adverse effects.[A34177] Nadolol was granted FDA approval on 10 December 1979.[L7922]
Indications and Usage Nadolol is indicated to treat angina pectoris and hypertension.[L7922] Another product formulated with [bendroflumethiazide] is indicated to treat hypertension.[L7925]
Marketing Status approved
ATC Code C07AA12
DrugBank ID DB01203
KEGG ID D00432
MeSH ID D009248
PubChem ID 39147
TTD Drug ID D05SHK
NDC Product Code 0904-7071; 42973-148; 62332-402; 69238-1125; 70771-1089; 72664-213; 76282-348; 76385-134; 51927-2776; 23155-732; 59762-0812; 0378-0028; 67787-348; 71335-2131; 76282-347; 46708-404; 70518-2139; 71335-1972; 59651-589; 60687-302; 68001-317; 68001-319; 68382-734; 69097-868; 69238-1124; 72664-211; 0781-8005; 10135-687; 59651-251; 60687-313; 67787-349; 68382-733; 69097-867; 69238-1123; 72664-212; 78670-100; 78670-101; 12780-0154; 0904-7070; 23155-731; 76385-135; 0781-8004; 51927-0238; 10135-688; 65015-718; 51079-812; 62332-404; 0378-1132; 0378-1171; 68001-318; 68382-732; 71335-0697; 0781-8006; 46708-402; 59762-0810; 59762-0811; 62332-403; 67787-347; 70771-1090; 23155-730; 59651-252; 70518-1755; 70771-1091; 76282-349; 76385-133; 10135-686; 69575-4016; 69097-869; 46708-403
UNII FEN504330V
Synonyms Nadolol | SQ-11725 | SQ 11725 | SQ11725 | Corgard | Solgol
Chemical Information
Molecular Formula C17H27NO4
CAS Registry Number 1403-22-1
SMILES CC(C)(C)NCC(COC1=CC=CC2=C1CC(C(C2)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Visual impairment06.02.10.013---
Vomiting07.01.07.003--
Weight increased13.15.01.006--
Wheezing22.03.01.0090.000345%
Mental status changes19.07.01.0010.000517%-
Cardiotoxicity02.11.01.009; 12.03.01.0070.000345%-
Hypoglycaemic seizure05.06.03.002; 14.06.03.002; 17.12.03.0150.000862%-
General physical health deterioration08.01.03.0180.000345%-
Tachyarrhythmia02.03.02.0080.000517%-
Cardio-respiratory distress02.05.01.011; 22.02.06.0080.000689%-
Neonatal hypoxia18.04.15.002; 22.11.02.0020.000862%-
Affect lability19.04.01.001---
Vascular insufficiency24.04.02.014---
Purpura non-thrombocytopenic01.01.04.006---
Pulseless electrical activity02.03.04.0200.000345%-
Disturbance in sexual arousal19.08.04.003---
Hepatic enzyme increased13.03.04.028---
Embolism24.01.01.009--
Abnormal behaviour19.01.01.001---
Decreased appetite08.01.09.028; 14.03.01.005--
Erectile dysfunction19.08.04.001; 21.03.01.007--
Supraventricular tachyarrhythmia02.03.03.0140.000345%-
Neuropsychological test abnormal13.07.06.001---
Oropharyngeal discomfort07.05.05.008; 22.12.03.015---
Oropharyngeal pain07.05.05.004; 22.12.03.016--
Foetal growth restriction18.03.01.0020.001551%
Multiple organ dysfunction syndrome08.01.03.0570.000517%
Small for dates baby18.04.02.0020.001206%-
Bradycardia neonatal02.03.02.019; 18.04.07.0040.000517%-
Poor feeding infant14.03.02.022; 18.04.06.0060.000345%-
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ADReCS-Target
Drug Name ADR Term Target
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