Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Moxonidine
Drug ID BADD_D01503
Description Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown to present blood pressure-independent beneficial effects on insulin resistance syndrome.
Indications and Usage For the treatment of mild to moderate essential or primary hypertension [L1025]. Effective as most first-line antihypertensives when used as monotherapy [A27137].
Marketing Status approved; investigational
ATC Code C02AC05
DrugBank ID DB09242
KEGG ID D05087
MeSH ID C043482
PubChem ID 4810
TTD Drug ID D0E9PK
NDC Product Code Not Available
UNII CC6X0L40GW
Synonyms moxonidine | 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine | moxonidin | Cynt | Physiotens | Moxon | Normatens | BE 5895 | BE-5895
Chemical Information
Molecular Formula C9H12ClN5O
CAS Registry Number 75438-57-2
SMILES CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Anxiety19.06.02.002--
Asthenia08.01.01.001---
Back pain15.03.04.005--
Bronchitis11.01.09.001; 22.07.01.001--
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dry mouth07.06.01.002--
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hypotension24.06.03.002--
Infection11.01.08.002---
Insomnia17.15.03.002; 19.02.01.002--
Nausea07.01.07.001--
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Orthostatic hypotension17.05.01.020; 24.06.03.004---
Pain08.01.08.004--
Pharyngitis07.05.07.004; 11.01.13.003; 22.07.03.004--
Pruritus23.03.12.001--
Rash23.03.13.001---
Sinusitis11.01.13.005; 22.07.03.007--
Sleep disorder19.02.04.001---
Somnolence17.02.04.006; 19.02.05.003--
Urticaria10.01.06.001; 23.04.02.001--
Vertigo04.04.01.003; 17.02.12.002--
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