| Drug Name |
Modafinil |
| Drug ID |
BADD_D01484 |
| Description |
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA. |
| Indications and Usage |
To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy. |
| Marketing Status |
approved; investigational |
| ATC Code |
N06BA07 |
| DrugBank ID |
DB00745
|
| KEGG ID |
D01832
|
| MeSH ID |
D000077408
|
| PubChem ID |
4236
|
| TTD Drug ID |
D07HQC
|
| NDC Product Code |
46438-0655; 63285-000; 63552-066; 70771-1051; 71205-477; 46438-0102; 65862-602; 60505-2526; 65862-601; 68071-2844; 69452-343; 65129-1102; 71205-544; 71335-1096; 63459-201; 68084-721; 70771-1052; 71335-1402; 72578-006; 63459-101; 23155-604; 71335-1793; 71610-685; 71335-1122; 72578-005; 50268-571; 55253-801; 57237-155; 60505-2527; 62332-385; 69452-342; 71335-1173; 0904-6423; 58175-0378; 63552-067; 23155-605; 46708-385; 55253-802; 63285-001; 46708-386; 63629-7315; 68084-621; 68788-7432; 68788-8280; 0904-6424; 0904-6791; 0904-6792; 72761-023; 42043-161; 50268-570; 57237-154; 62332-386; 63629-4998; 68788-8079; 63415-0036; 65862-576; 42043-160; 43353-925 |
| UNII |
R3UK8X3U3D
|
| Synonyms |
Modafinil | 2-((Diphenylmethyl)sulfinyl)acetamide | Vigil | Sparlon | Nuvigil | Alertec | Benzhydrylsulfinylacetamide | Armodafinil | 2-((R)-(Diphenylmethyl)sulfinyl)acetamide | R-Modafinil | R Modafinil | Provigil | Modiodal | CRL 40476 | CRL-40476 |
