| Drug Name |
Midazolam hydrochloride |
| Drug ID |
BADD_D01460 |
| Description |
Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties.[A173842] It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action.[A173842] Midazolam is available by oral, rectal, intranasal, intramuscular (IM), and intravenous (IV) routes and has been used in various biomedical applications, including dentistry, cardiac surgery, and endoscopic procedures as pre-anesthetic medication, and as an adjunct to local anesthesia.[F2977]
This drug was initially approved by the US FDA in 1985, and has been approved for various indications since.[FDA label] In late 2018, the intramuscular preparation was approved by the FDA for the treatment of status epilepticus in adults.[FDA label] In May 2019, the nasal spray of midazolam was approved for the acute treatment of distinctive intermittent, stereotypic seizure episodes in patients 12 years of age and older. Midazolam is considered a schedule IV drug in the United States due to the low potential for abuse and low risk of dependence.[L5074] |
| Indications and Usage |
**Intravenous**
Indicated for promoting preoperative sedation, anxiolysis, anesthesia induction, or amnesia.[F2434]
**Intramuscular**
Indicated for the treatment of status epilepticus in adults.[FDA label]
**Nasal**
Indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in patients with epilepsy 12 years of age and older.[L6559] |
| Marketing Status |
approved; illicit |
| ATC Code |
N05CD08 |
| DrugBank ID |
DB00683
|
| KEGG ID |
D00696
|
| MeSH ID |
D008874
|
| PubChem ID |
43032
|
| TTD Drug ID |
D0U6LM
|
| NDC Product Code |
0904-7113; 11704-650; 23155-600; 51754-2131; 55154-4743; 0409-2308; 0904-7114; 51754-2130; 60687-576; 0409-2305; 76045-002; 76045-003; 63323-411; 68094-764; 70860-600; 70860-601; 0574-0150; 76045-001; 17511-134; 23155-601; 44567-611; 63323-412; 0054-3566; 17478-523; 0404-9916; 17478-524; 68094-762; 48087-0103; 44567-610; 63629-2534; 68083-108; 52584-308; 68083-106; 0409-2587; 0409-2596; 76045-211 |
| UNII |
W7TTW573JJ
|
| Synonyms |
Midazolam | Midazolam Maleate | Maleate, Midazolam | Dormicum | Versed | Midazolam Hydrochloride | Hydrochloride, Midazolam | Ro 21-3981 | Ro 21 3981 | Ro 213981 |
