Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Metolazone
Drug ID BADD_D01444
Description A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss.
Indications and Usage For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.
Marketing Status approved
ATC Code C03BA08
DrugBank ID DB00524
KEGG ID D00431
MeSH ID D008788
PubChem ID 4170
TTD Drug ID D01WLC
NDC Product Code 64330-115; 46708-532; 51407-431; 51407-432; 0527-2217; 72888-053; 72888-054; 76385-136; 10135-765; 50742-351; 51079-023; 60687-624; 62332-532; 71406-113; 71406-115; 65392-2201; 0185-0055; 51079-024; 63629-7875; 0527-2215; 71335-1944; 72888-052; 69575-4023; 60687-635; 0378-6172; 69292-562; 0527-2216; 71406-114; 46708-534; 63629-8733; 71610-285; 76385-137; 43353-999; 0185-5050; 62332-534; 69292-564; 69292-566; 69766-067; 0185-5600; 50742-350; 51407-433; 63629-8722; 0378-6173; 0904-6916; 17381-254; 0904-7138; 10135-767; 43353-931; 50742-349; 62332-533; 0378-6174; 71610-142; 76385-138; 43353-890; 0904-7139; 10135-766; 46708-533
UNII TZ7V40X7VX
Synonyms Metolazone | Microx | Mykrox | Zaroxolyn | Diulo | SR-720-22 | SR 720 22 | SR72022
Chemical Information
Molecular Formula C16H16ClN3O3S
CAS Registry Number 17560-51-9
SMILES CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Loss of consciousness17.02.04.004---
Malaise08.01.01.003--
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Nervousness19.06.02.003---
Neuropathy peripheral17.09.03.003---
Nocturia20.02.03.001---
Oedema08.01.07.006; 14.05.06.010---
Orthostatic hypotension17.05.01.020; 24.06.03.004---
Pain08.01.08.004--
Palpitations02.11.04.012--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005; 23.03.03.094--
Peripheral coldness08.01.09.010; 23.06.04.008; 24.04.03.006---
Petechiae01.01.03.002; 23.06.01.003; 24.07.06.004---
Photosensitivity reaction23.03.09.003--
Polyuria20.02.03.0020.000525%-
Pruritus23.03.12.001--
Purpura01.01.04.003; 23.06.01.004; 24.07.06.005--
Rash23.03.13.0010.000350%-
Restlessness17.02.05.021; 19.11.02.002--
Shock24.06.02.002---
Sinus congestion22.04.06.001---
Skin exfoliation23.03.07.003---
Skin necrosis23.03.03.011---
Somnolence17.02.04.006; 19.02.05.003--
Stevens-Johnson syndrome10.01.01.045; 11.07.01.005; 12.03.01.014; 23.03.01.007--
Stupor17.02.04.007; 19.02.05.0040.000350%-
Swelling08.01.03.015---
Syncope02.11.04.015; 17.02.04.008; 24.06.02.0120.000525%
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