Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methyl aminolevulinate hydrochloride
Drug ID BADD_D01424
Description Methyl aminolevulinate is a prodrug that is metabolised to Protoporphyrin IX (a photosensitizer) used in photodynamic therapy.
Indications and Usage For topical use, in combination with 570 to 670 nm wavelength red light illumination, in the treatment of non-hyperkeratotic actinic keratoses of the face and scalp in immunocompetent patients when used in conjunction with lesion preparation (debridement using a sharp dermal curette).
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB00992
KEGG ID D04988
MeSH ID C475457
PubChem ID 157921
TTD Drug ID Not Available
NDC Product Code 46016-7940
UNII 7S73606O1A
Synonyms methyl 5-aminolevulinate | MAOP cpd | methyl aminolaevulinate | Metvix
Chemical Information
Molecular Formula C6H12ClNO3
CAS Registry Number 79416-27-6
SMILES COC(=O)CCC(=O)CN.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash23.03.13.001---
Rash pustular11.01.12.002; 23.03.10.003--
Scab23.03.03.004---
Skin exfoliation23.03.07.003---
Skin hyperpigmentation23.05.01.003--
Skin infection11.01.12.003; 23.11.04.007--
Skin ulcer23.07.03.003; 24.04.03.007--
Skin warm23.03.03.014---
Squamous cell carcinoma16.16.01.002---
Swelling08.01.03.015---
Ulcer08.03.06.001---
Urticaria10.01.06.001; 23.04.02.001--
Vitreous detachment06.09.01.002; 12.01.04.005---
Application site eczema08.02.01.019; 12.07.01.019; 23.03.04.015---
Skin tightness23.03.03.018---
Application site discharge08.02.01.039; 12.07.01.039; 23.03.03.049---
Skin burning sensation17.02.06.009; 23.03.03.021---
Skin oedema23.06.04.001---
Skin haemorrhage23.06.07.001; 24.07.01.103---
Sensitisation08.01.05.009; 10.02.01.012---
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