| Drug Name |
Mesalamine |
| Drug ID |
BADD_D01397 |
| Description |
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease [A174022]. It is considered to be the active moiety of sulphasalazine. (From Martindale, The Extra Pharmacopoeia, 30th ed) Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent [A174019]. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules [A174019]. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022] |
| Indications and Usage |
Mesalazine is indicated for the induction of remission in patients with active or mild to moderate acute exacerbations of ulcerative colitis and for the maintenance of remission of ulcerative colitis [FDA Label], [L5101]. Prescribing information for mesalazine in the UK also indicates the medication for the maintenance of remission of Crohn's ileo-colitis [L5101]. |
| Marketing Status |
approved |
| ATC Code |
A07EC02 |
| DrugBank ID |
DB00244
|
| KEGG ID |
D00377
|
| MeSH ID |
D019804
|
| PubChem ID |
4075
|
| TTD Drug ID |
D0C4YC
|
| NDC Product Code |
0023-5854; 49452-0450; 21922-045; 59762-0117; 62332-724; 68382-452; 68682-113; 54127-0945; 62331-064; 58914-501; 60687-650; 0037-0066; 67877-717; 68382-435; 0023-5801; 11014-0129; 0904-6832; 51927-1078; 57297-192; 57451-1141; 54092-100; 54092-189; 59651-397; 0037-0022; 60687-397; 63304-175; 0378-1375; 69918-560; 0781-7088; 12598-9155; 24528-0003; 49957-511; 59285-037; 63552-042; 42291-563; 51407-274; 63629-2397; 65649-103; 70710-1302; 42419-024; 49706-0882; 70966-0035; 45802-098; 50268-577; 63629-8678; 0527-3012; 70771-1513; 0591-2245; 12598-9151; 12598-9554; 47621-059; 54127-0947; 70600-006; 45802-929; 46708-724; 0023-5901; 54092-476; 60687-556; 62559-420; 63629-8679; 63629-8827; 64980-282; 68382-711; 70518-3239; 70710-1543; 70771-1110; 49964-0015; 54127-0950; 62350-0076; 62756-115; 63552-043; 16714-245; 42291-564; 50090-3002; 0023-5853; 0472-1915; 70771-1353; 70771-1625; 12598-5158; 12598-9553; 12651-582; 62331-060; 62512-0072; 31722-005; 45802-923; 54092-191; 59762-0118; 60687-408; 63304-089; 70748-214; 12598-9154; 59651-396; 62991-2705; 67454-001; 68743-476; 16714-830; 0093-5907; 43353-884; 60687-703; 70771-1071; 12598-5163; 49706-8821; 54127-0943; 0093-9224 |
| UNII |
4Q81I59GXC
|
| Synonyms |
Mesalamine | Mesalazine | m-Aminosalicylic Acid | m Aminosalicylic Acid | 5-Aminosalicylic Acid | 5 Aminosalicylic Acid | meta-Aminosalicylic Acid | meta Aminosalicylic Acid | Asacol | Asacolon | Ascolitin | Canasa | Claversal | Fivasa | Salofalk | Lixacol | Mesalamine Hydrochloride | Hydrochloride, Mesalamine | Mesalamine Monosodium Salt | Monosodium Salt, Mesalamine | Mesasal | Novo-5 ASA | Novo 5 ASA | Pentasa | Rowasa | 5-Aminosalicylate | 5 Aminosalicylate |
