Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mepivacaine
Drug ID BADD_D01387
Description A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Indications and Usage For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.
Marketing Status approved; vet_approved
ATC Code N01BB03
DrugBank ID DB00961
KEGG ID D08181
MeSH ID D008619
PubChem ID 4062
TTD Drug ID D0WO8W
NDC Product Code 52932-0745
UNII B6E06QE59J
Synonyms Mepivacaine | Mepivacaina Braun | Isogaine | Meaverin | Mecain | Mepihexal | Mepivacain-Injektopas | Mepivacain Injektopas | Mepivacaine Hydrochloride | Mepivacaine Monohydrochloride | Mepivastesin | Polocaine | Scandinibsa | Scandonest | Scandicain | Scandicaine | Carbocaine | Carbocaïne | Isocaine
Chemical Information
Molecular Formula C15H22N2O
CAS Registry Number 96-88-8
SMILES CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Respiratory arrest22.02.01.0090.000268%-
Respiratory paralysis17.01.04.010; 22.02.06.003---
Retinal artery occlusion06.10.01.005; 24.01.07.0030.000357%-
Seizure17.12.03.0010.000804%
Shock24.06.02.002---
Sinus tachycardia02.03.03.0100.000179%
Sneezing22.12.03.024--
Somnolence17.02.04.006; 19.02.05.0030.000393%
Speech disorder17.02.08.003; 19.19.02.002; 22.12.03.0270.000357%-
Spinal anaesthesia25.01.03.001---
Swelling08.01.03.015---
Syncope02.11.04.015; 17.02.04.008; 24.06.02.0120.000572%
Tachycardia02.03.02.0070.000268%-
Tension19.06.02.005---
Tinnitus04.04.01.002; 17.04.07.004--
Tremor17.01.06.002--
Urinary incontinence17.05.01.008; 20.02.02.010--
Urinary retention20.02.02.011--
Urticaria10.01.06.001; 23.04.02.0010.000482%
Ventricular arrhythmia02.03.04.006--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
Clonic convulsion17.12.03.0080.000357%-
Hypoaesthesia oral07.05.05.003; 17.02.06.0210.000393%-
Paraesthesia oral07.05.05.035; 17.02.06.008---
Pulseless electrical activity02.03.04.0200.000179%-
Eye movement disorder06.05.02.008; 17.02.05.0250.000179%-
Cranial nerve paralysis17.04.01.002---
Neonatal asphyxia18.04.15.005; 22.11.02.0060.000268%-
Neonatal respiratory depression18.04.17.002; 22.11.02.0090.000447%-
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