Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Megestrol acetate
Drug ID BADD_D01372
Description 17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Indications and Usage For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used for the palliative management of recurrent, inoperable, or metastatic breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
Marketing Status approved; investigational; vet_approved
ATC Code Not Available
DrugBank ID DB00351
KEGG ID D00952
MeSH ID D019290
PubChem ID 11683
TTD Drug ID Not Available
NDC Product Code 17856-0060; 0555-0606; 0555-0607; 46439-8722; 24979-041; 49884-289; 63739-549; 66689-020; 68094-361; 68094-250; 71335-2181; 0904-7236; 71052-116; 49884-290; 68094-174; 0904-3571; 0009-5030; 0121-0945; 49884-907; 64380-158; 63592-0109; 60429-433; 64380-159; 64380-160; 51927-1670; 68094-063; 63629-7631; 71205-943; 60722-1009; 0121-4776; 50383-859; 0904-7072
UNII TJ2M0FR8ES
Synonyms Megestrol Acetate | Acetate, Megestrol | Lin-Megestrol | Lin Megestrol | LinMegestrol | Maygace | Megace | Megostat | Megestat | Megefren | Mestrel | Nu-Megestrol | Nu Megestrol | NuMegestrol | Borea | Apo-Megestrol | Apo Megestrol | ApoMegestrol
Chemical Information
Molecular Formula C24H32O4
CAS Registry Number 595-33-5
SMILES CC1=CC2C(CCC3(C2CCC3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Flatulence07.01.04.002--
Fluid retention14.05.06.002; 20.01.02.003---
Glucose tolerance decreased13.02.02.004---
Glucose tolerance impaired05.06.02.001; 14.06.02.001--
Gynaecomastia05.05.02.003; 21.05.04.003--
Headache17.14.01.001--
Hepatomegaly09.01.05.001---
Herpes virus infection11.05.02.008---
Hypercalcaemia05.04.01.002; 14.04.01.003--
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Hypotension24.06.03.0020.001218%
Increased appetite08.01.09.027; 14.03.01.003---
Infection11.01.08.002---
Insomnia17.15.03.002; 19.02.01.002--
Intracranial pressure increased17.07.02.0020.001107%-
Lethargy08.01.01.008; 17.02.04.003; 19.04.04.004--
Leukopenia01.02.02.001---
Libido decreased19.08.03.001; 21.03.02.005--
Lung disorder22.02.07.001---
Malaise08.01.01.003--
Meningioma16.30.01.005; 17.20.01.0050.003597%-
Menopausal symptoms21.02.02.002---
Mood swings19.04.03.001---
Nausea07.01.07.001--
Neoplasm malignant16.16.01.001---
Neuropathy peripheral17.09.03.003---
Oedema08.01.07.006; 14.05.06.010---
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