| Drug Name |
Medroxyprogesterone acetate |
| Drug ID |
BADD_D01366 |
| Description |
Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties.[A14848] MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prevent pregnancy, manage pain in endometriosis, prevent pregnancy, and is also used in palliative care for endometrial and renal carcinoma.[L8657,L8660,L8663,L8666,L8669]
Medroxyprogesterone acetate was granted FDA approval on 18 June 1959.[L8657] |
| Indications and Usage |
Medroxyprogesterone acetate (MPA) oral tablets are indicated to treat secondary amenorrhea, reduce the incidence of endometrial hyperplasia in postmenopausal women, and to treat abnormal uterine bleeding due to hormonal imbalance, not organic pathology.[L8657] Oral tablets containing MPA and conjugated estrogens are indicated to prevent postmenopausal osteoporosis and to treat moderate to severe menopausal symptoms such as vasomotor symptoms, vulvar atrophy, and vaginal atrophy.[L8660] Subcutaneous MPA is indicated to prevent pregnancy and manage pain associated with endometriosis.[L8663] Intramuscular MPA is indicated to prevent pregnancy,[L8666] and at higher concentrations for palliative treatment of endometrial or renal carcinoma.[L8669] |
| Marketing Status |
approved; investigational |
| ATC Code |
Not Available |
| DrugBank ID |
DB00603
|
| KEGG ID |
D00951
|
| MeSH ID |
D017258
|
| PubChem ID |
6279
|
| TTD Drug ID |
Not Available
|
| NDC Product Code |
51552-0790; 60722-1006; 0009-0051; 0009-0746; 63629-8744; 63629-8825; 66993-370; 68788-8112; 0555-0872; 12866-1099; 16714-999; 0009-0065; 50090-5619; 50090-5747; 53002-3570; 63629-2612; 66993-371; 70518-3336; 38779-1422; 62991-1474; 50090-4251; 59762-0055; 55150-330; 55289-160; 59762-4537; 63629-8824; 67296-0396; 67457-887; 69097-539; 0548-5400; 46439-8749; 65089-0022; 16714-981; 0009-0287; 0009-7376; 62756-090; 70121-1480; 0548-5410; 65089-0002; 24201-150; 0009-4709; 50090-0490; 50090-0491; 68788-9899; 70518-3070; 0555-0873; 51927-0112; 59762-0056; 63187-382; 70121-1467; 0555-0779; 72789-043; 63592-0089; 55150-329; 59762-0058; 60687-105; 62756-091; 0548-5701; 52221-118; 0009-0286; 50090-0166; 50102-591; 0548-5711; 71205-118; 0009-5097; 46439-8712; 50090-3328; 63629-8826; 49452-4725; 50090-5925; 59762-4538 |
| UNII |
C2QI4IOI2G
|
| Synonyms |
Medroxyprogesterone Acetate | 6-alpha-Methyl-17alpha-hydroxyprogesterone Acetate | 6 alpha Methyl 17alpha hydroxyprogesterone Acetate | Depo-Medroxyprogesterone Acetate | Depo Medroxyprogesterone Acetate | (6 alpha)-17-(Acetoxy)-6-methylpregn-4-ene-3,20-dione | Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6alpha)- | Medroxyprogesterone 17-Acetate | Medroxyprogesterone 17 Acetate | Depo-Provera | Depo Provera | DepoProvera | Farlutal | Gestapuran | Curretab | Medroxyprogesterone 17-Acetate, (6 beta)-Isomer | Perlutex | Provera | Veramix | Cycrin | Medroxyprogesterone 17-Acetate, (6 alpha,17 alpha)-Isomer |
